ArticleRegeneration (Oxford, England)2015
Gene expression during the first 28 days of axolotl limb regeneration I: Experimental design and global analysis of gene expression.
Article in Regeneration (Oxford, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed.
- Are axolotls resistant to cancer? Possible explanations.Molecular biology reports · 2026Review
- Leukemic Transdifferentiation: From Pathological Plasticity to Dendritic Cell-Based Immunotherapy.Biomedicines · 2025Review
- hoxc12/c13 as key regulators for rebooting the developmental program in Xenopus limb regeneration.Nature communications · 2024Article
- Limb blastema formation: How much do we know at a genetic and epigenetic level?The Journal of biological chemistry · 2023Review
- Intestine-enriched apolipoprotein b orthologs are required for stem cell progeny differentiation and regeneration in planarians.Nature communications · 2022Article
- Post-amputation reactive oxygen species production is necessary for axolotls limb regeneration.Frontiers in cell and developmental biology · 2022Article
- Wnt Signaling Coordinates the Expression of Limb Patterning Genes During Axolotl Forelimb Development and Regeneration.Frontiers in cell and developmental biology · 2022Article
- Chemical genetics of regeneration: Contrasting temporal effects of CoClDevelopmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Large-scale variation in single nucleotide polymorphism density within the laboratory axolotl (Ambystoma mexicanum).Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Towards comparative analyses of salamander limb regeneration.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2021Review
- Timing Does Matter: Nerve-Mediated HDAC1 Paces the Temporal Expression of Morphogenic Genes During Axolotl Limb Regeneration.Frontiers in cell and developmental biology · 2021Article
- von Willebrand factor D and EGF domains is an evolutionarily conserved and required feature of blastemas capable of multitissue appendage regeneration.Evolution & development · 2020Article
- Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration.eLife · 2020Article
- Article
- Functional Characterization of the Lin28/let-7 Circuit During Forelimb Regeneration inFrontiers in cell and developmental biology · 2020Article
- Integrative Analysis of Axolotl Gene Expression Data from Regenerative and Wound Healing Limb Tissues.Scientific reports · 2019Article
- Comparative transcriptomics of limb regeneration: Identification of conserved expression changes among three species of Ambystoma.Genomics · 2019Article
- Electrical stimulation shifts healing/scarring towards regeneration in a rat limb amputation model.Scientific reports · 2019Article
- Deep evolutionary origin of limb and fin regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Longitudinal 16S rRNA data derived from limb regenerative tissue samples of axolotl Ambystoma mexicanum.Scientific data · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
While it is appreciated that global gene expression analyses can provide novel insights about complex biological processes, experiments are generally insufficiently powered to achieve this goal. Here we report the results of a robust microarray experiment of axolotl forelimb regeneration. At each of 20 post-amputation time points, we estimated gene expression for 10 replicate RNA samples that were isolated from 1 mm of heterogeneous tissue collected from the distal limb tip. We show that the limb transcription program diverges progressively with time from the non-injured state, and divergence among time adjacent samples is mostly gradual. However, punctuated episodes of transcription were identified for five intervals of time, with four of these coinciding with well-described stages of limb regeneration-amputation, early bud, late bud, and pallet. The results suggest that regeneration is highly temporally structured and regulated by mechanisms that function within narrow windows of time to coordinate transcription within and across cell types of the regenerating limb. Our results provide an integrative framework for hypothesis generation using this complex and highly informative data set.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.