ArticleExperimental and therapeutic medicine2016
Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury.
Article in Experimental and therapeutic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Fluoxetine attenuates hepatic ischemia-reperfusion injury through antioxidant, anti-inflammatory and anti-apoptotic mechanisms.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Protective effects of BPC 157 in rats with experimentally induced lower extremity ischemia-reperfusion injury.Scientific reports · 2026Article
- Protective effect of melatonin against age-related ischemia-reperfusion injury is associated with the NLRP3 inflammasome pathway.Journal of physiology and biochemistry · 2026Article
- Metformin alleviates doxorubicin-induced hepatic damage by modulating oxidative stress: a molecular, biochemical, and histopathological approach in a rat model.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- IPCellular & molecular biology letters · 2024Article
- Melatonin as a multifunctional modulator: emerging insights into its role in health, reproductive efficiency, and productive performance in livestock.Frontiers in physiology · 2024Review
- 4-phenyl butyric acid improves hepatic ischemia/reperfusion and affects gene expression of ABC transporter Abcc5 in rats.Croatian medical journal · 2023Article
- Antioxidant Intervention against Male Infertility: Time to Design Novel Strategies.Biomedicines · 2022Review
- Melatonin and its protective role in attenuating warm or cold hepatic ischaemia/reperfusion injury.Cell proliferation · 2021Review
- The effects of melatonin on possible damage that will occur on adipocytokines and liver tissue by coadministration of fructose and bisphenol a (BPA).Environmental science and pollution research international · 2020Article
- Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies.Journal of pineal research · 2020Review
- The effect of Liv-52 on liver ischemia reperfusion damage in rats.BMC pharmacology & toxicology · 2020Article
- Melatonin ameliorates sodium valproate-induced hepatotoxicity in rats.Molecular biology reports · 2020Article
- Possible application of melatonin treatment in human diseases of the biliary tract.American journal of physiology. Gastrointestinal and liver physiology · 2019Review
- Protective effect of troxerutin and cerebroprotein hydrolysate injection on cerebral ischemia through inhibition of oxidative stress and promotion of angiogenesis in rats.Molecular medicine reports · 2019Article
- Prostaglandin E1 Preconditioning Attenuates Liver Ischemia Reperfusion Injury in a Rat Model of Extrahepatic Cholestasis.BioMed research international · 2018Article
- Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas.Cellular and molecular life sciences : CMLS · 2017Review
- Effects of Melatonin on Liver Injuries and Diseases.International journal of molecular sciences · 2017Review
- Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress.Molecules (Basel, Switzerland) · 2016Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to investigate the effects of melatonin (MT) on liver function and lipid peroxidation following hepatic ischemia-reperfusion injury (IRI). A total of 66 male Sprague-Dawley rats were randomly assigned into three groups: Normal control (N) group, ischemia-reperfusion (IR) group and the MT-treated group. A hepatic IRI model was developed by blocking the first porta hepatis, and subsequently restoring hepatic blood inflow after 35 min. Following reperfusion, changes in the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) were detected by a chemical method at various time points. In the MT group, the MDA levels were significantly reduced (P<0.05) at all time points, as compared with the IR group. Furthermore, SOD activity was significantly increased (P<0.05) in the MT group, as compared with the IR group at all time points; and the levels of GSH in the MT group were significantly higher (P<0.05) than those of the IR group at 2, 4, and 8 h post-reperfusion. The levels of ALT, AST and LDH were significantly reduced in the MT group at each time point, as compared with that of the IR group (P<0.05). In conclusion, MT exhibits potent antioxidant properties that may create favorable conditions for the recovery of liver function following IRI.
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