Evidence map›Paper›PMID 27168815›Full record

ArticleExperimental and therapeutic medicine2016

Expression of pituitary tumor-transforming 2 in human glioblastoma cell lines and its role in glioblastoma tumorigenesis.

Yunbao Guo, Yimeng Shao, Jing Chen, Songbai Xu, Xingdong Zhang, Haiyan Liu

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  5. Article
  6. The Oncogenic Roles ofDiagnostics (Basel, Switzerland) · 2020
    Article
  7. Article
  8. Article
  9. Article
  10. Biomarkers in Tumorigenesis Using Cancer Cell Lines: A Systematic ReviewAsian Pacific journal of cancer prevention : APJCP · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Yunbao GuoDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Yimeng ShaoOperating Room, Central Hospital of Changchun, Changchun, Jilin 130011, P.R. China.
Jing ChenDepartment of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.
Songbai XuDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Xingdong ZhangDepartment of Anatomy, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China.
Haiyan LiuDepartment of Anatomy, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China.
Jilin University · CNFirst Hospital of Jilin University · CNJilin Medical University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to investigate the association between the expression of pituitary tumor-transforming 2 (PTTG2), and cell proliferation, invasion and apoptosis in glioblastoma. The U251 human glioblastoma cell line was transfected with the pcDNA-PTTG2 and small interfering (si)RNA-PTTG2 plasmids using Lipofectamine 2000. The expression of PTTG2 in U251 glioblastoma cells was determined using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis. The association between PTTG2 expression, and cell proliferation, invasion and apoptosis

Indexed as

flow cytometryglioblastomaMatrigel transwell assayMTT assaypituitary tumor-transforming 2

Identifiers

PMID27168815
PMCPMC4840751
OpenAlexW2296994710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.