Evidence map›Paper›PMID 27168786›Full record

ArticleExperimental and therapeutic medicine2016

Notch signaling is active in normal mouse middle ear epithelial cells.

Xiang Liu, Hai-Bin Sheng, Rui Ma, Juan-Mei Yang, Wen-Wei Luo, Xiao-Yu Yang, Dong-Dong Ren, Fang-Lu Chi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. An in vitro model of murine middle ear epithelium.Disease models & mechanisms · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiang LiuDepartment of Otology and Skull Base Surgery, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai 200031, P.R. China; Shanghai Auditory Medical Center, Ministry of Health, Fudan University, Shanghai 200031, P.R. China; Key Laboratory of Hearing Science, Ministry of Health, Fudan University, Shanghai 200031, P.R. China.
Hai-Bin ShengDepartment of Otology and Skull Base Surgery, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai 200031, P.R. China; Shanghai Auditory Medical Center, Ministry of Health, Fudan University, Shanghai 200031, P.R. China; Key Laboratory of Hearing Science, Ministry of Health, Fudan University, Shanghai 200031, P.R. China.
Rui MaDepartment of Otology and Skull Base Surgery, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai 200031, P.R. China; Shanghai Auditory Medical Center, Ministry of Health, Fudan University, Shanghai 200031, P.R. China; Key Laboratory of Hearing Science, Ministry of Health, Fudan University, Shanghai 200031, P.R. China; Department of Research Center, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai 200031, P.R. China.
Juan-Mei YangDepartment of Otology and Skull Base Surgery, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai 200031, P.R. China; Shanghai Auditory Medical Center, Ministry of Health, Fudan University, Shanghai 200031, P.R. China; Key Laboratory of Hearing Science, Ministry of Health, Fudan University, Shanghai 200031, P.R. China.
Wen-Wei LuoDepartment of Otology and Skull Base Surgery, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai 200031, P.R. China; Shanghai Auditory Medical Center, Ministry of Health, Fudan University, Shanghai 200031, P.R. China; Key Laboratory of Hearing Science, Ministry of Health, Fudan University, Shanghai 200031, P.R. China.
Xiao-Yu YangDepartment of Otology and Skull Base Surgery, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai 200031, P.R. China; Shanghai Auditory Medical Center, Ministry of Health, Fudan University, Shanghai 200031, P.R. China; Key Laboratory of Hearing Science, Ministry of Health, Fudan University, Shanghai 200031, P.R. China.
Dong-Dong RenDepartment of Otology and Skull Base Surgery, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai 200031, P.R. China; Shanghai Auditory Medical Center, Ministry of Health, Fudan University, Shanghai 200031, P.R. China; Key Laboratory of Hearing Science, Ministry of Health, Fudan University, Shanghai 200031, P.R. China.
Fang-Lu ChiDepartment of Otology and Skull Base Surgery, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai 200031, P.R. China; Shanghai Auditory Medical Center, Ministry of Health, Fudan University, Shanghai 200031, P.R. China; Key Laboratory of Hearing Science, Ministry of Health, Fudan University, Shanghai 200031, P.R. China.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucous cell metaplasia/hyperplasia in the middle ear epithelium is associated with the occurrence of otitis media with effusion during infections. However, the mechanism by which Notch signaling regulates cell fate in the middle ear epithelium is unclear. The aim of the present study was to elucidate this mechanism by investigating the localization of Notch receptors, such as Notch1 and Notch2, and Notch ligands, such as Jagged1, in the normal mouse middle ear epithelium (NMMEE) using immunofluorescence. Furthermore, the mRNA expression levels of Notch receptors and ligands were evaluated using reverse transcription polymerase chain reaction (PCR). The effects of the γ-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine

Indexed as

DAPTdifferentiationmucous cell metaplasianotch signalingotitis mediaproliferation

Identifiers

PMID27168786
PMCPMC4840515
OpenAlexW2295829019

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.