ArticleResearch in pharmaceutical sciences
Protective effect of crocin on liver toxicity induced by morphine.
Article in Research in pharmaceutical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 60 citations in OpenAlex.
- Sex and dose differences in morphine administration on renal function, inflammatory and apoptotic markers in male and female Wistar rats.Current research in physiology · 2025Article
- Protective effects of pistachio hydroalcoholic extract on morphine-induced analgesic tolerance and dependence: investigating the impact of oxidative stress.Research in pharmaceutical sciences · 2024Article
- Interaction of aerobic exercise and crocin improves memory, learning and hypocampic tau and neurotrophins gene expression in rats treated with trimethytin as a model of Alzheimer's disease.Molecular biology reports · 2024Article
- Crocetin Enhances Temozolomide Efficacy in Glioblastoma Therapy Through Multiple Pathway Suppression.Current neurovascular research · 2024Article
- Effects of toxicants on endoplasmic reticulum stress and hepatic cell fate determination.Toxicological research · 2023Review
- Crocin lessens desipramine-induced phospholipidosis biomarker levels via targeting oxidative stress- related PI3K/Akt/mTOR signaling pathways in the rat liver.Acta bio-medica : Atenei Parmensis · 2023Article
- Mesoporous Polydopamine Nanoparticles Attenuate Morphine Tolerance in Neuropathic Pain Rats by Inhibition of Oxidative Stress and Restoration of the Endogenous Antioxidant System.Antioxidants (Basel, Switzerland) · 2021Article
- The Effects of Crocin on Bone and Cartilage Diseases.Frontiers in pharmacology · 2021Review
- Neurotoxic, Hepatotoxic and Nephrotoxic Effects of Tramadol Administration in Rats.Journal of molecular neuroscience : MN · 2020Article
- Crocetin suppresses the growth and migration in HCT-116 human colorectal cancer cells by activating the p-38 MAPK signaling pathway.Research in pharmaceutical sciences · 2020Article
- Crocetin Improves Dengue Virus-Induced Liver Injury.Viruses · 2020Article
- Repeated Administration of Clinical Doses of Tramadol and Tapentadol Causes Hepato- and Nephrotoxic Effects in Wistar Rats.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Toxic Effects of Methotrexate on Rat Kidney Recovered by Crocin as a Consequence of Antioxidant Activity and Lipid Peroxidation PreventionIranian biomedical journal · 2020Article
- Protective Effects of Crocin Against Hepatic Damages in D-galactose Aging Model in Rats.Iranian journal of pharmaceutical research : IJPR · 2020Article
- Effect ofJournal of diabetes and metabolic disorders · 2019Article
- The meaning of confounding adjustment in the presence of multiple versions of treatment: an application to organ transplantation.European journal of epidemiology · 2019Article
- Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice.Saudi journal of biological sciences · 2018Article
- Effect of Thymoquinone on Reproductive Parameter in Morphine-treated Male Mice.Advanced biomedical research · 2018Article
- The Effects of Thymoquinone Against Morphine-induced Damages on Male Mice Liver.International journal of preventive medicine · 2018Article
- Pancreatic protective and hypoglycemic effects ofResearch in pharmaceutical sciences · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crocin, a bioactive molecule of saffron can be purely isolated from the saffron extract. It has different pharmacological effects such as antioxidant and anticancer activities. Morphine is an opioid analgesic drug. It is mainly metabolized in liver and causes devastating effects. It can increase the generation of free radicals. This study was designed to evaluate the protective role of crocin against morphine-induced toxicity in the mouse liver. In this study, various doses of crocin (12.5, 25 and 50 mg/kg) and crocin plus morphine were administered interaperitoneally once daily to 48 male mice for 20 consecutive days. These mice were randomly assigned to 8 groups of 6 each. The liver weight and histology, aspartate amino transferase, alanine aminotransferase, alkaline phosphatase (ALP) and serum nitric oxide levels were studied. The results indicated that morphine administration significantly decreased liver weight and increased the mean diameter of hepatocyte, central hepatic vein diameters, liver enzyme levels, and blood serum nitric oxide level compared to saline group (P<0.05). However, crocin administration significantly boosted liver weight and decreased the mean diameter of hepatocyte, central hepatic vein, liver enzymes and nitric oxide levels in all groups compared to the group received morphine alone (P<0.05). It seems that crocin administration could protect the liver damage induced by morphine. The antioxidant effect of crocin may be a major reason for its positive impact on liver parameters.
Indexed as
Identifiers
27168751PMC4852656W2300094116What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.