Evidence map›Paper›PMID 27168746›Full record

ReviewJournal of geriatric cardiology : JGC2016

Androgen actions on endothelium functions and cardiovascular diseases.

Jing-Jing Cai, Juan Wen, Wei-Hong Jiang, Jian Lin, Yuan Hong, Yuan-Shan Zhu

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of geriatric cardiology : JGC, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jing-Jing CaiDepartment of Cardiology of the Third Xiangya Hospital, Central South University, Changsha, China; The Center of Clinical Pharmacology of the Third Xiangya Hospital, Central South University, Changsha, China.
Juan WenDepartment of Cardiology of the Third Xiangya Hospital, Central South University, Changsha, China; The Center of Clinical Pharmacology of the Third Xiangya Hospital, Central South University, Changsha, China.
Wei-Hong JiangDepartment of Cardiology of the Third Xiangya Hospital, Central South University, Changsha, China.
Jian LinDepartment of Medicine/Endocrinology, Weill Cornell Medical College, NY, USA.
Yuan HongDepartment of Cardiology of the Third Xiangya Hospital, Central South University, Changsha, China; The Center of Clinical Pharmacology of the Third Xiangya Hospital, Central South University, Changsha, China.
Yuan-Shan ZhuDepartment of Medicine/Endocrinology, Weill Cornell Medical College, NY, USA; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.
Central South University · CN

Funding

Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024996 · NCRR · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2007 to 2011
$49.6M
NCATS NIH HHS UL1 TR002384NCRR NIH HHS UL1 RR024996
6 · The paper itself

Abstract

The roles of androgens on cardiovascular physiology and pathophysiology are controversial as both beneficial and detrimental effects have been reported. Although the reasons for this discrepancy are unclear, multiple factors such as genetic and epigenetic variation, sex-specificity, hormone interactions, drug preparation and route of administration may contribute. Recently, growing evidence suggests that androgens exhibit beneficial effects on cardiovascular function though the mechanism remains to be elucidated. Endothelial cells (ECs) which line the interior surface of blood vessels are distributed throughout the circulatory system, and play a crucial role in cardiovascular function. Endothelial progenitor cells (EPCs) are considered an indispensable element for the reconstitution and maintenance of an intact endothelial layer. Endothelial dysfunction is regarded as an initiating step in development of atherosclerosis and cardiovascular diseases. The modulation of endothelial functions by androgens through either genomic or nongenomic signal pathways is one possible mechanism by which androgens act on the cardiovascular system. Obtaining insight into the mechanisms by which androgens affect EC and EPC functions will allow us to determine whether androgens possess beneficial effects on the cardiovascular system. This in turn may be critical in the prevention and therapy of cardiovascular diseases. This article seeks to review recent progress in androgen regulation of endothelial function, the sex-specificity of androgen actions, and its clinical applications in the cardiovascular system.

Indexed as

AndrogenCardiovascular diseasesEndothelial cellsEndotheliumEstrogen

Identifiers

PMID27168746
PMCPMC4854959
OpenAlexW2300178697

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.