ArticleJournal of exposure science & environmental epidemiology2017
Temporal variability of urinary cadmium in spot urine samples and first morning voids.
Article in Journal of exposure science & environmental epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Reflections on the NIEHS Virtual Consortium funding mechanism (ViCTER) and what it has taught us about the future of transdisciplinary science.Toxicology · 2025Article
- A protocol for the prospective study of urinary cadmium with risk of fracture, bone loss, and muscle loss.JBMR plus · 2024Article
- A State-of-the-Science Review on Metal Biomarkers.Current environmental health reports · 2023Review
- Urinary cadmium and stroke - a case-cohort study in Danish never-smokers.Environmental research · 2021Article
- Urine cadmium and acute myocardial infarction among never smokers in the Danish Diet, Cancer and Health cohort.Environment international · 2021Article
- Low-Level Cadmium Exposure and Atherosclerosis.Current environmental health reports · 2021Review
- Assessment of exposure to toxic metals and measures to address deficiency of essential trace elements in young children in rural Hubei, China.Environmental science and pollution research international · 2020Article
- Variability and exposure classification of urinary levels of non-essential metals aluminum, antimony, barium, thallium, tungsten and uranium in healthy adult men.Journal of exposure science & environmental epidemiology · 2019Article
- Temporal stability of urinary cadmium in samples collected several years apart in a population of older persons.International journal of hygiene and environmental health · 2019Article
- Is Urinary Cadmium a Biomarker of Long-term Exposure in Humans? A Review.Current environmental health reports · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Cadmium is a carcinogenic heavy metal. Urinary levels of cadmium are considered to be an indicator of long-term body burden, as cadmium accumulates in the kidneys and has a half-life of at least 10 years. However, the temporal stability of the biomarker in urine samples from a non-occupationally exposed population has not been rigorously established. We used repeated measurements of urinary cadmium (U-Cd) in spot urine samples and first morning voids from two separate cohorts, to assess the temporal stability of the samples. Urine samples from two cohorts including individuals of both sexes were measured for cadmium and creatinine. The first cohort (Home Observation of Perinatal Exposure (HOPE)) consisted of 21 never-smokers, who provided four first morning urine samples 2-5 days apart, and one additional sample roughly 1 month later. The second cohort (World Trade Center-Health Program (WTC-HP)) consisted of 78 individuals, including 52 never-smokers, 22 former smokers and 4 current smokers, who provided 2 spot urine samples 6 months apart, on average. Intra-class correlation was computed for groups of replicates from each individual to assess temporal variability. The median creatinine-adjusted U-Cd level (0.19 and 0.21 μg/g in the HOPE and WTC-HP, respectively) was similar to levels recorded in the United States by the National Health and Nutrition Examination Survey. The intra-class correlation (ICC) was high (0.76 and 0.78 for HOPE and WTC-HP, respectively) and similar between cohorts, irrespective of whether samples were collected days or months apart. Both single spot or first morning urine cadmium samples show good to excellent reproducibility in low-exposure populations.
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Registered trials
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