ArticleInvestigative ophthalmology & visual science2016
Cupping in the Monkey Optic Nerve Transection Model Consists of Prelaminar Tissue Thinning in the Absence of Posterior Laminar Deformation.
Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- A Novel Model of Traumatic Optic Neuropathy Under Direct Vision Through the Anterior Orbital Approach in Non-human Primates.Neuroscience bulletin · 2025Article
- Evaluation of lamina cribrosa curvature index in different types of glaucoma.International ophthalmology · 2024Article
- Retrolaminar Demyelination of Structurally Intact Axons in Nonhuman Primate Experimental Glaucoma.Investigative ophthalmology & visual science · 2024Article
- Under Pressure: Lamina Cribrosa Pore Path Tortuosity in Response to Acute Pressure Modulation.Translational vision science & technology · 2023Article
- Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update.Nutrients · 2022Review
- Comparison of Lamina Cribrosa Morphology in Eyes with Ocular Hypertension and Normal-Tension Glaucoma.Investigative ophthalmology & visual science · 2020Article
- Factors Influencing Central Lamina Cribrosa Depth: A Multicenter Study.Investigative ophthalmology & visual science · 2018Article
- Crowded optic nerve head evaluation with optical coherence tomography in anterior ischemic optic neuropathy.Eye (London, England) · 2017Article
- The connective tissue phenotype of glaucomatous cupping in the monkey eye - Clinical and research implications.Progress in retinal and eye research · 2017Review
- Experimental Glaucoma Causes Optic Nerve Head Neural Rim Tissue Compression: A Potentially Important Mechanism of Axon Injury.Investigative ophthalmology & visual science · 2016Article
Corrections and comments
- Erratum issuedErratum.2016
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo use optical coherence tomography (OCT) to test the hypothesis that optic nerve head (ONH) "cupping" in the monkey optic nerve transection (ONT) model does not include posterior laminar deformation.
methodsFive monkeys (aged 5.5-7.8 years) underwent ONH and retinal nerve fiber layer (RNFL) OCT imaging five times at baseline and biweekly following unilateral ONT until euthanization at ∼40% RNFL loss. Retinal nerve fiber layer thickness (RNFLT) and minimum rim width (MRW) were calculated from each pre- and post-ONT imaging session. The anterior lamina cribrosa surface (ALCS) was delineated within baseline and pre-euthanasia data sets. Significant ONT versus control eye pre-euthanasia change in prelaminar tissue thickness (PLTT), MRW, RNFLT, and ALCS depth (ALCSD) was determined using a linear mixed-effects model. Eye-specific change in each parameter exceeded the 95% confidence interval constructed from baseline measurements.
resultsAnimals were euthanized 49 to 51 days post ONT. Overall ONT eye change from baseline was significant for MRW (-26.2%, P = 0.0011), RNFLT (-43.8%, P < 0.0001), PLTT (-23.8%, P = 0.0013), and ALCSD (-20.8%, P = 0.033). All five ONT eyes demonstrated significant eye-specific decreases in MRW (-23.7% to -31.8%) and RNFLT (-39.6% to -49.7%). Four ONT eyes showed significant PLTT thinning (-23.0% to -28.2%). The ALCS was anteriorly displaced in three of the ONT eyes (-25.7% to -39.2%). No ONT eye demonstrated posterior laminar displacement.
conclusionsSeven weeks following surgical ONT in the monkey eye, ONH cupping involves prelaminar and rim tissue thinning without posterior deformation of the lamina cribrosa.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.