Evidence map›Paper›PMID 27168314›Full record

ArticleThe Journal of antibiotics2016

DNA sequence-selective C8-linked pyrrolobenzodiazepine-heterocyclic polyamide conjugates show anti-tubercular-specific activities.

Federico Brucoli, Juan D Guzman, Mohammad A Basher, Dimitrios Evangelopoulos, Eleanor McMahon, Tulika Munshi, Timothy D McHugh, Keith R Fox, Sanjib Bhakta

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in The Journal of antibiotics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Federico BrucoliSchool of Sport and Science, Institute of Biomedical and Environmental Health Research (IBEHR), University of the West of Scotland, Paisley, UK.
Juan D GuzmanDepartment of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, University of London, London, UK.
Mohammad A BasherCentre for Biological Sciences, University of Southampton, Southampton, UK.
Dimitrios EvangelopoulosDepartment of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, University of London, London, UK.
Eleanor McMahonDepartment of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, University of London, London, UK.
Tulika MunshiDepartment of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, University of London, London, UK.
Timothy D McHughCentre for Clinical Microbiology, University College London, London, UK.
Keith R FoxCentre for Biological Sciences, University of Southampton, Southampton, UK.
Sanjib BhaktaDepartment of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, University of London, London, UK.
Birkbeck, University of London · GBInstitute of Structural and Molecular Biology · GBUniversity College London · GBUniversity of Southampton · GBUniversity of the West of Scotland · GB

Funding

Medical Research Council G0801956Medical Research Council G0802079
6 · The paper itself

Abstract

New chemotherapeutic agents with novel mechanisms of action are in urgent need to combat the tuberculosis pandemic. A library of 12 C8-linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD)-heterocyclic polyamide conjugates (1-12) was evaluated for anti-tubercular activity and DNA sequence selectivity. The PBD conjugates were screened against slow-growing Mycobacterium bovis Bacillus Calmette-Guérin and M. tuberculosis H

Indexed as

Sequence Analysis, DNAAnimalsAntitubercular AgentsBase SequenceBenzodiazepinesDeoxyribonuclease IDNA, BacterialDNA FootprintingEscherichia coliIsoniazidMiceMicrobial Sensitivity TestsMycobacterium bovisMycobacterium tuberculosisNylonsPseudomonas putidaAntitubercular AgentsBenzodiazepinesDeoxyribonuclease IDNA, BacterialIsoniazidNylonsPyrrolespyrrolo(2,1-c)(1,4)benzodiazepineRifampin

Identifiers

PMID27168314
OpenAlexW2365743838

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.