ReviewCurrent opinion in anaesthesiology2016
New insights in the systemic and molecular underpinnings of general anesthetic actions mediated by γ-aminobutyric acid A receptors.
Review in Current opinion in anaesthesiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Comparison of the effects of remimazolam and dexmedetomidine on the quality of recovery in functional endoscopic sinus surgery: a randomized clinical trial.BMC anesthesiology · 2024Trial
- Efficacy of pretreatment with remimazolam on prevention of propofol-induced injection pain in patients undergoing gastroscopy.Scientific reports · 2023Trial
- SAGE-217, A Novel GABAClinical pharmacokinetics · 2020Trial
- From bugs to brain: unravelling the GABA signalling networks in the brain-gut-microbiome axis.Brain : a journal of neurology · 2025Review
- A chronopharmacological comparison of ciprofol and propofol: focus on sedation and side effects.Frontiers in molecular neuroscience · 2025Article
- Does total hip arthroplasty result in intercostal nerve injury? A case report and literature review.Open medicine (Warsaw, Poland) · 2023Article
- Role of GABAFrontiers in cellular neuroscience · 2022Article
- GABAJournal, genetic engineering & biotechnology · 2021Review
- Isoflurane Potentiation of GABAInternational journal of molecular sciences · 2020Article
- Neuroendocrine, epigenetic, and intergenerational effects of general anesthetics.World journal of psychiatry · 2020Review
- The Estradiol Synthesis Inhibitor Formestane Diminishes the Ability of Sevoflurane to Induce Neurodevelopmental Abnormalities in Male Rats.Frontiers in systems neuroscience · 2020Article
- Intergenerational Effects of Sevoflurane in Young Adult Rats.Anesthesiology · 2019Article
- [67-year-old male in resuscitation room for treatment after traffic accident : Preparation for the medical specialist examination: Part 7].Der Anaesthesist · 2019Article
- GABANeuropharmacology · 2018Review
- Surgery increases cell death and induces changes in gene expression compared with anesthesia alone in the developing piglet brain.PloS one · 2017Article
- Effects of Etomidate on GABAergic and Glutamatergic Transmission in Rat Thalamocortical Slices.Neurochemical research · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
purpose of reviewThe review highlights novel insights into the role of γ-aminobutyric acid A (GABAA) receptors in mediating clinically relevant actions of anesthetic agents. RECENT
findingsGABAA receptors in the hippocampus are located on glutamatergic pyramidal cells and GABAergic interneurons. Etomidate-induced inhibition of a synaptic correlate of learning and memory is caused by receptors on nonpyramidal neurons, likely on interneurons that incorporate α5 subunits. Selective enhancement of α2 subunit containing GABAA receptors in the spinal cord provides antihyperalgesia against inflammatory and neuropathic pain without causing sedation, motor impairment, and tolerance development. Inflammation, traumatic brain injury, and exposure to anesthetic agents modify the expression patterns of GABAA receptors in a subtype-specific manner. These modifications may persist for weeks. The neuroactive steroid alphaxalone causes fast-onset and short-duration anesthesia in humans. Cardiovascular and respiratory side-effects are less severe than with propofol. SUMMARY: Identification of the molecular and cellular substrates involved in anesthesia and insights into disease and drug-induced alterations in the expression patterns of GABAA receptors in the central nervous system are emphasizing the need for individualized anesthesia care. Introducing neuroactive steroids into clinical anesthesia is expected to reduce cardiovascular and respiratory side-effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.