ArticlePloS one2016
Two UV-Sensitive Photoreceptor Proteins, Opn5m and Opn5m2 in Ray-Finned Fish with Distinct Molecular Properties and Broad Distribution in the Retina and Brain.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Non-visual opsins and their role in circadian photoentrainment.Eye and vision (London, England) · 2026Review
- The physiological functions of OPN5m.Eye and vision (London, England) · 2025Review
- Discovery and design of photocyclic animal opsins: potential application to gene therapy from non-visual opsin research.Eye and vision (London, England) · 2025Review
- A key spectral tuning site of UV-sensitive vertebrate non-visual opsin Opn5.Cellular and molecular life sciences : CMLS · 2025Article
- Development of visible light-sensitive human neuropsin (OPN5) via single amino acid substitution.FEBS letters · 2025Article
- Divergent spatiotemporal integration of whole-field visual motion in medaka and zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Evolution of the Nonvisual and Visual Opsin Gene Repertoire in Ray-Finned Fishes.Genome biology and evolution · 2025Article
- Day length regulates gonadotrope proliferation and reproduction via an intra-pituitary pathway in the model vertebrate Oryzias latipes.Communications biology · 2024Article
- All Light, Everywhere? Photoreceptors at Nonconventional Sites.Physiology (Bethesda, Md.) · 2024Review
- Cell-type expression and activation by light of neuropsins in the developing and matureFrontiers in cellular neuroscience · 2023Article
- Whole genome assembly of the armored loricariid catfish Ancistrus triradiatus highlights herbivory signatures.Molecular genetics and genomics : MGG · 2022Article
- Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells.The Journal of comparative neurology · 2022Article
- Amino acid residue at position 188 determines the UV-sensitive bistable property of vertebrate non-visual opsin Opn5.Communications biology · 2022Article
- Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Seasonal variation in UVA light drives hormonal and behavioural changes in a marine annelid via a ciliary opsin.Nature ecology & evolution · 2021Article
- Unexpected molecular diversity of vertebrate nonvisual opsin Opn5.Biophysical reviews · 2020Review
- Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing.Cell reports · 2020Article
- Zebrafish Circadian Clock Entrainment and the Importance of Broad Spectral Light Sensitivity.Frontiers in physiology · 2020Article
- Localization of the ultraviolet-sensor Opn5m and its effect on myopia-related gene expression in the late-embryonic chick eye.Biochemistry and biophysics reports · 2019Article
- Cartography of rhodopsin-like G protein-coupled receptors across vertebrate genomes.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Opn5 is a group within the opsin family of proteins that is responsible for visual and non-visual photoreception in animals. It consists of several subgroups, including Opn5m, the only subgroup containing members found in most vertebrates, including mammals. In addition, recent genomic information has revealed that some ray-finned fishes carry paralogous genes of Opn5m while other fishes have no such genes. Here, we report the molecular properties of the opsin now called Opn5m2 and its distributions in both the retina and brain. Like Opn5m, Opn5m2 exhibits UV light-sensitivity when binding to 11-cis-retinal and forms a stable active state that couples with Gi subtype of G protein. However, Opn5m2 does not bind all-trans-retinal and exhibits exclusive binding to 11-cis-retinal, whereas many bistable opsins, including fish Opn5m, can bind directly to all-trans-retinal as well as 11-cis-retinal. Because medaka fish has lost the Opn5m2 gene from its genome, we compared the tissue distribution patterns of Opn5m in medaka fish, zebrafish, and spotted gar, in addition to the distribution patterns of Opn5m2 in zebrafish and spotted gar. Opn5m expression levels showed a gradient along the dorsal-ventral axis of the retina, and preferential expression was observed in the ventral retina in the three fishes. The levels of Opn5m2 showed a similar gradient with preferential expression observed in the dorsal retina. Opn5m expression was relatively abundant in the inner region of the inner nuclear layer, while Opn5m2 was expressed in the outer edge of the inner nuclear layer. Additionally, we could detect Opn5m expression in several brain regions, including the hypothalamus, of these fish species. Opn5m2 expression could not be detected in zebrafish brain, but was clearly observed in limited brain regions of spotted gar. These results suggest that ray-finned fishes can generally utilize UV light information for non-image-forming photoreception in a wide range of cells in the retina and brain.
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