ArticlePsychophysiology2016
Psychometric properties of startle and corrugator response in NPU, affective picture viewing, and resting state tasks.
Article in Psychophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- The effect of ketamine on affective modulation of the startle reflex and its resting-state brain correlates.Scientific reports · 2023Trial
- Acute orexin antagonism selectively modulates anticipatory anxiety in humans: implications for addiction and anxiety.Translational psychiatry · 2022Trial
- Neurophysiological and clinical effects of the NMDA receptor antagonist lanicemine (BHV-5500) in PTSD: A randomized, double-blind, placebo-controlled trial.Depression and anxiety · 2021Trial
- The novel vasopressin receptor (V1aR) antagonist SRX246 reduces anxiety in an experimental model in humans: a randomized proof-of-concept study.Psychopharmacology · 2021Trial
- Mechanistic link between right prefrontal cortical activity and anxious arousal revealed using transcranial magnetic stimulation in healthy subjects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Acute prazosin administration does not reduce stressor reactivity in healthy adults.Psychopharmacology · 2019Trial
- Longitudinal associations between binge drinking and changes in behavioral and neural threat reactivity in youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- A mechanistic trial of the neurobiology of extinction learning and intraparietal sulcus stimulation: Protocol.Contemporary clinical trials communications · 2026Article
- Wait for It: Defensive Reactivity and Individual Differences in Contrast Avoidance in the NPU-Reward Task.Psychophysiology · 2025Article
- Whose Signals Are Being Amplified? Toward a More Equitable Clinical Psychophysiology.Clinical psychological science : a journal of the Association for Psychological Science · 2024Article
- Transdiagnostic Fear and Anxiety: Prospective Prediction Using the No-Threat, Predictable Threat, and Unpredictable Threat Task.Biological psychiatry global open science · 2023Article
- Continuous Theta-Burst Stimulation to the Right Dorsolateral Prefrontal Cortex May Increase Potentiated Startle in Healthy Individuals.Biological psychiatry global open science · 2023Article
- Cross-species anxiety tests in psychiatry: pitfalls and promises.Molecular psychiatry · 2022Review
- Back to Basics: The Importance of Measurement Properties in Biological Psychiatry.Neuroscience and biobehavioral reviews · 2021Review
- Aerobic exercise reduces anxiety and fear ratings to threat and increases circulating endocannabinoids in women with and without PTSD.Mental health and physical activity · 2021Article
- A way forward for anxiolytic drug development: Testing candidate anxiolytics with anxiety-potentiated startle in healthy humans.Neuroscience and biobehavioral reviews · 2020Review
- Behavioral and neural sensitivity to uncertain threat in individuals with alcohol use disorder: Associations with drinking behaviors and motives.Addiction biology · 2020Article
- Low-frequency parietal repetitive transcranial magnetic stimulation reduces fear and anxiety.Translational psychiatry · 2020Article
- The impact of startle reactivity to unpredictable threat on the relation between bullying victimization and internalizing psychopathology.Journal of psychiatric research · 2019Review
- Modeling anxiety in healthy humans: a key intermediate bridge between basic and clinical sciences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
The current study provides a comprehensive evaluation of critical psychometric properties of commonly used psychophysiology laboratory tasks/measures within the NIMH RDoC. Participants (N = 128) completed the no-shock, predictable shock, unpredictable shock (NPU) task, affective picture viewing task, and resting state task at two study visits separated by 1 week. We examined potentiation/modulation scores in NPU (predictable or unpredictable shock vs. no-shock) and affective picture viewing tasks (pleasant or unpleasant vs. neutral pictures) for startle and corrugator responses with two commonly used quantification methods. We quantified startle potentiation/modulation scores with raw and standardized responses. We quantified corrugator potentiation/modulation in the time and frequency domains. We quantified general startle reactivity in the resting state task as the mean raw startle response during the task. For these three tasks, two measures, and two quantification methods, we evaluated effect size robustness and stability, internal consistency (i.e., split-half reliability), and 1-week temporal stability. The psychometric properties of startle potentiation in the NPU task were good, but concerns were noted for corrugator potentiation in this task. Some concerns also were noted for the psychometric properties of both startle and corrugator modulation in the affective picture viewing task, in particular, for pleasant picture modulation. Psychometric properties of general startle reactivity in the resting state task were good. Some salient differences in the psychometric properties of the NPU and affective picture viewing tasks were observed within and across quantification methods.
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