ArticleHuman brain mapping2016
Spectral and spatial changes of brain rhythmic activity in response to the sustained thermal pain stimulation.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Neuroimaging Insights into the Public Health Burden of Neuropsychiatric Disorders: A Systematic Review of Electroencephalography-Based Cognitive Biomarkers.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Analgesic effects and neural oscillatory mechanisms of music-synchronized virtual reality intervention.Journal of neuroengineering and rehabilitation · 2025Trial
- Identifying and Engaging Neuronal Oscillations by Transcranial Alternating Current Stimulation in Patients With Chronic Low Back Pain: A Randomized, Crossover, Double-Blind, Sham-Controlled Pilot Study.The journal of pain · 2019Trial
- Article
- Chronic pain and oscillatory neuroplasticity: Review on impaired compensatory network responses in resting-state electroencephalography.Brain network disorders · 2026Article
- The moderating role of trait mindfulness on pain perception: insights from pain-related electroencephalography oscillations.Pain reports · 2025Article
- EEG power spectra encode both labour pain intensity and uterine contractions during the latent phase of labour.British journal of anaesthesia · 2025Article
- EEG alpha/beta features as a biomarker for quantifying pain in patients with lumbar disk herniation.Frontiers in neuroscience · 2025Article
- Harnessing theta waves: tACS as a breakthrough in alleviating post-stroke chronic pain.Frontiers in neuroscience · 2025Review
- Intracranial EEG signals disentangle multi-areal neural dynamics of vicarious pain perception.Nature communications · 2024Article
- Neural processes responsible for the translation of sustained nociceptive inputs into subjective pain experience.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The Analysis of Spontaneous Electroencephalogram (EEG) in Chronic Low Back Pain Patients Compared with Healthy Subjects.Medical journal of the Islamic Republic of Iran · 2023Article
- EEG Recordings as Biomarkers of Pain Perception: Where Do We Stand and Where to Go?Pain and therapy · 2022Review
- Distinct spatio-temporal and spectral brain patterns for different thermal stimuli perception.Scientific reports · 2022Article
- A Temporospatial Study of Sympathetic Skin Response and Electroencephalogram in Oral Mucosa Thermal Perception.Frontiers in neuroscience · 2022Article
- Transcranial photobiomodulation and thermal stimulation induce distinct topographies of EEG alpha and beta power changes in healthy humans.Scientific reports · 2021Observational
- Characterization of Source-Localized EEG Activity During Sustained Deep-Tissue Pain.Brain topography · 2021Article
- Sex-differences in network level brain dynamics associated with pain sensitivity and pain interference.Human brain mapping · 2021Article
- Low Back Pain Assessment Based on Alpha Oscillation Changes in Spontaneous Electroencephalogram (EEG).Neural plasticity · 2021Article
- Neuromodulation Management of Chronic Neuropathic Pain in The Central Nervous system.Advanced functional materials · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The aim of this study was to investigate the neurophysiological correlates of pain caused by sustained thermal stimulation. A group of 21 healthy volunteers was studied. Sixty-four channel continuous electroencephalography (EEG) was recorded while the subject received tonic thermal stimulation. Spectral changes extracted from EEG were quantified and correlated with pain scales reported by subjects, the stimulation intensity, and the time course. Network connectivity was assessed to study the changes in connectivity patterns and strengths among brain regions that have been previously implicated in pain processing. Spectrally, a global reduction in power was observed in the lower spectral range, from delta to alpha, with the most marked changes in the alpha band. Spatially, the contralateral region of the somatosensory cortex, identified using source localization, was most responsive to stimulation status. Maximal desynchrony was observed when stimulation was present. The degree of alpha power reduction was linearly correlated to the pain rating reported by the subjects. Contralateral alpha power changes appeared to be a robust correlate of pain intensity experienced by the subjects. Granger causality analysis showed changes in network level connectivity among pain-related brain regions due to high intensity of pain stimulation versus innocuous warm stimulation. These results imply the possibility of using noninvasive EEG to predict pain intensity and to study the underlying pain processing mechanism in coping with prolonged painful experiences. Once validated in a broader population, the present EEG-based approach may provide an objective measure for better pain management in clinical applications. Hum Brain Mapp 37:2976-2991, 2016. © 2016 Wiley Periodicals, Inc.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.