ArticleReproductive toxicology (Elmsford, N.Y.)2016
Mono-2-ethylhexyl phthalate disrupts neurulation and modifies the embryonic redox environment and gene expression.
Article in Reproductive toxicology (Elmsford, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Mathematical modeling of the interaction between yolk utilization and fish growth in zebrafish, Danio rerio.Development (Cambridge, England) · 2021Article
- Spatiotemporal evaluation of the mouse embryonic redox environment and histiotrophic nutrition following treatment with valproic acid and 1,2-dithiole-3-thione during early organogenesis.Reproductive toxicology (Elmsford, N.Y.) · 2021Article
- Effects and mechanisms of phthalates' action on neurological processes and neural health: a literature review.Pharmacological reports : PR · 2021Review
- Embryonic exposures to mono-2-ethylhexyl phthalate induce larval steatosis in zebrafish independent of Nrf2a signaling.Journal of developmental origins of health and disease · 2021Article
- Effect of environmental contamination on female and male gametes - A lesson from bovines.Animal reproduction · 2020Review
- [Effects of Shoutai pills on immune function and oxidative stress in pregnant rats with di(2-ethylhexyl) phthalate exposure].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- The Redox Theory of Development.Antioxidants & redox signaling · 2020Review
- Fetal growth in environmental epidemiology: mechanisms, limitations, and a review of associations with biomarkers of non-persistent chemical exposures during pregnancy.Environmental health : a global access science source · 2019Review
- A mechanistic model for thiol redox dynamics in the organogenesis stage rat conceptus.Reproductive toxicology (Elmsford, N.Y.) · 2018Article
- Pancreatic beta cells are a sensitive target of embryonic exposure to butylparaben in zebrafish (Danio rerio).Birth defects research · 2018Article
- Biodegradation of Di-(2-ethylhexyl) Phthalate by Rhodococcus ruber YC-YT1 in Contaminated Water and Soil.International journal of environmental research and public health · 2018Article
- Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebrafish (Danio rerio).Chemosphere · 2018Article
- Mono-2-ethylhexyl phthalate (MEHP) alters histiotrophic nutrition pathways and epigenetic processes in the developing conceptus.The Journal of nutritional biochemistry · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Mono-2-ethylhexl phthalate (MEHP) is the primary metabolite of di-2-ethylhexyl phthalate (DEHP), a ubiquitous contaminant in plastics. This study sought to determine how structural defects caused by MEHP in mouse whole embryo culture were related to temporal and spatial patterns of redox state and gene expression. MEHP reduced morphology scores along with increased incidence of neural tube defects. Glutathione (GSH) and cysteine (Cys) concentrations fluctuated spatially and temporally in embryo (EMB) and visceral yolk sac (VYS) across the 24h culture. Redox potentials (Eh) for GSSG/GSH were increased by MEHP in EMB (12h) but not in VYS. CySS/CyS Eh in EMB and VYS were significantly increased at 3h and 24h, respectively. Gene expression at 6h showed that MEHP induced selective alterations in EMB and VYS for oxidative phosphorylation and energy metabolism pathways. Overall, MEHP affects neurulation, alters Eh, and spatially alters the expression of metabolic genes in the early organogenesis-stage mouse conceptus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.