ReviewAnesthesia and analgesia2016
Mapping General Anesthetic Sites in Heteromeric γ-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes.
Review in Anesthesia and analgesia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Convergent Recruitment of Cerebellar Purkinje Cells by Mechanistically Diverse General Anesthetics.Journal of neurochemistry · 2025Article
- Spiro Hydantoins Can Reverse the Action of Positive Allosteric Modulators on GABAACS medicinal chemistry letters · 2025Article
- Novel Spiro-Barbiturates Can Reverse the Action of General Anesthetics on the GABAJournal of medicinal chemistry · 2025Article
- Article
- Precisely Providing Analgesia through Selectively Targeting the GABAThe Journal of pharmacology and experimental therapeutics · 2024Article
- An Update on Stiripentol Mechanisms of Action: A Narrative Review.Advances in therapy · 2024Review
- Effects of propofol on presynaptic synapsin phosphorylation in the mouse brain in vivo.Brain research · 2024Article
- Phenols and GABAFrontiers in pharmacology · 2024Review
- Substituted Cysteine Modification and Protection with n-Alkyl-MTS Reagents Quantifies Steric Changes Induced by a Mutation in Anesthetic Binding Sites on GABA Type A Receptors.Molecular pharmacology · 2023Article
- Role of ferroptosis in hypoxic preconditioning to reduce propofol neurotoxicity.Frontiers in pharmacology · 2023Article
- Photomotor Responses in Zebrafish and Electrophysiology Reveal Varying Interactions of Anesthetics Targeting Distinct Sites on γ-Aminobutyric Acid Type A Receptors.Anesthesiology · 2022Article
- GABAJournal, genetic engineering & biotechnology · 2021Review
- Direct Structural Insights into GABATrends in biochemical sciences · 2021Review
- Substituted Cysteine Modification and Protection withMolecular pharmacology · 2021Article
- Roles of Neuropeptide S in Anesthesia, Analgesia, and Sleep.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Modulation of α1β3γ2 GABAProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Understanding the Effects of Anesthesia on Cortical Electrophysiological Recordings: A Scoping Review.International journal of molecular sciences · 2021Article
- New Evidence of Receptor-based Pharmacology Underlying a Volatile Anesthetic Effect.Anesthesiology · 2020Article
- Allopregnanolone Enhances GABAergic Inhibition in Spinal Motor Networks.International journal of molecular sciences · 2020Article
- The general anesthetic etomidate and fenamate mefenamic acid oppositely affect GABAEuropean biophysics journal : EBJ · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
IV general anesthetics, including propofol, etomidate, alphaxalone, and barbiturates, produce important actions by enhancing γ-aminobutyric acid type A (GABAA) receptor activation. In this article, we review scientific studies that have located and mapped IV anesthetic sites using photoaffinity labeling and substituted cysteine modification protection. These anesthetics bind in transmembrane pockets between subunits of typical synaptic GABAA receptors, and drugs that display stereoselectivity also show remarkably selective interactions with distinct interfacial sites. These results suggest strategies for developing new drugs that selectively modulate distinct GABAA receptor subtypes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.