ArticleJournal of applied clinical medical physics2016
Geometric dose prediction model for hemithoracic intensity-modulated radiation therapy in mesothelioma patients with two intact lungs.
Article in Journal of applied clinical medical physics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Criteria-calibration approaches to deep learning-based cervical cancer radiation treatment auto-planning.Radiation oncology (London, England) · 2025Article
- Knowledge-based radiation treatment planning: A data-driven method survey.Journal of applied clinical medical physics · 2021Review
- Knowledge-based planning for intensity-modulated radiation therapy: A review of data-driven approaches.Medical physics · 2019Review
- Artificial Intelligence in Radiotherapy Treatment Planning: Present and Future.Technology in cancer research & treatment · 2019Review
- Automation in intensity modulated radiotherapy treatment planning-a review of recent innovations.The British journal of radiology · 2018Review
- Malignant pleural mesothelioma: adjuvant therapy with radiation therapy.Annals of translational medicine · 2017Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The presence of two intact lungs makes it challenging to reach a tumoricidal dose with hemithoracic pleural intensity-modulated radiation therapy (IMRT) in patients with malignant pleural mesothelioma (MPM) who underwent pleurectomy/decortications or have unresectable disease. We developed an anatomy-based model to predict attainable prescription dose before starting optimization. Fifty-six clinically delivered IMRT plans were analyzed regarding correlation of prescription dose and individual and total lung volumes, planning target volume (PTV), ipsilateral normal lung volume and ratios: contralateral/ipsilateral lung (CIVR); contralateral lung/PTV (CPVR); ipsilateral lung /PTV (IPVR); ipsilateral normal lung /total lung (INTLVR); ipsilateral normal lung/PTV (INLPVR). Spearman's rank correlation and Fisher's exact test were used. Correlation between mean ipsilateral lung dose (MILD) and these volume ratios and between prescription dose and single lung mean doses were studied. The prediction models were validated in 23 subsequent MPM patients. CIVR showed the strongest correlation with dose (R=0.603,p<0.001) and accurately predicted prescription dose in the validation cases. INLPVR and MILD as well as MILD and prescription dose were significantly correlated (R=-0.784,p<0.001 and R=0.554,p<0.001, respectively) in the training and validation cases. Parameters obtainable directly from planning scan anatomy predict achievable prescription doses for hemithoracic IMRT treatment of MPM patients with two intact lungs. PACS number(s): 87.55.de, 87.55.dk.
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