Evidence map›Paper›PMID 27167218›Full record

ArticlePloS one2016

MiasDB: A Database of Molecular Interactions Associated with Alternative Splicing of Human Pre-mRNAs.

Yongqiang Xing, Xiujuan Zhao, Tao Yu, Dong Liang, Jun Li, Guanyun Wei, Guoqing Liu, Xiangjun Cui, Hongyu Zhao, Lu Cai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Bioinformatics challenges and perspectives when studying the effect of epigenetic modifications on alternative splicing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yongqiang XingSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Xiujuan ZhaoSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Tao YuSchool of Science, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Dong LiangSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Jun LiSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Guanyun WeiSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Guoqing LiuSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Xiangjun CuiSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Hongyu ZhaoSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Lu CaiSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Inner Mongolia University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alternative splicing (AS) is pervasive in human multi-exon genes and is a major contributor to expansion of the transcriptome and proteome diversity. The accurate recognition of alternative splice sites is regulated by information contained in networks of protein-protein and protein-RNA interactions. However, the mechanisms leading to splice site selection are not fully understood. Although numerous databases have been built to describe AS, molecular interaction databases associated with AS have only recently emerged. In this study, we present a new database, MiasDB, that provides a description of molecular interactions associated with human AS events. This database covers 938 interactions between human splicing factors, RNA elements, transcription factors, kinases and modified histones for 173 human AS events. Every entry includes the interaction partners, interaction type, experimental methods, AS type, tissue specificity or disease-relevant information, a simple description of the functionally tested interaction in the AS event and references. The database can be queried easily using a web server (http://47.88.84.236/Miasdb). We display some interaction figures for several genes. With this database, users can view the regulation network describing AS events for 12 given genes.

Indexed as

Alternative SplicingDatabases, GeneticGene Regulatory NetworksRNA Splice SitesExonsHistonesHumansInternetIntronsProtein Interaction MappingProtein KinasesResponse ElementsRNA PrecursorsTranscription FactorsHistonesProtein KinasesRNA PrecursorsRNA Splice SitesTranscription Factors

Identifiers

PMID27167218
PMCPMC4864242
OpenAlexW2380001763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.