ArticlePloS one2016
What Is Going On Around Here? Intolerance of Uncertainty Predicts Threat Generalization.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- Effect of Tryptophan Depletion on Conditioned Threat Memory Expression: Role of Intolerance of Uncertainty.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Trial
- Better Safe Than Sorry? Exploratory Associations Between Fear-Learning Processes and Later Paranoia in Threat-Exposed Adolescents in Standardized Virtual Reality Environments.Schizophrenia bulletin open · 2026Article
- Mediating effect of fear of happiness between intolerance of uncertainty and anxiety among Lebanese adults.Global mental health (Cambridge, England) · 2026Article
- Generalized expectancy of threat in threatening compared to safe contexts.Social cognitive and affective neuroscience · 2025Article
- Fear learning and generalization in youth with early-stage transdiagnostic psychiatric symptoms and the impact of acute exercise.Frontiers in psychiatry · 2025Article
- Effects of outcome uncertainty related to gain and loss, performance feedback, and individual differences during a cognitive control task.Frontiers in psychology · 2025Article
- The effect of typicality training on costly safety behavior generalization.Psychological research · 2024Article
- Secure attachment priming inhibits the generalization of conditioned fear.BMC psychology · 2024Article
- Overgeneralization of conditioned fear in patients with social anxiety disorder.Frontiers in psychiatry · 2024Article
- Intolerance of Uncertainty, Job Satisfaction and Work Performance in Turkish Healthcare Professionals: Mediating Role of Psychological Capital.International journal of public health · 2024Article
- Intolerance of Uncertainty as a Cognitive Vulnerability for Obsessive-Compulsive Disorder: A Qualitative Review.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2023Article
- Role of Cue Training, Context, and Stimulus Intensity on Fear Generalization in Humans.Behavioral sciences (Basel, Switzerland) · 2023Article
- Keep me updated! Social support as a coping strategy to reduce the perceived threat caused by the cognitive availability of COVID-19 relevant information.Current psychology (New Brunswick, N.J.) · 2023Article
- Facing Uncertainty: A Comparison of Hierarchical and Variable Exposure Interventions for Contamination Fear.Journal of obsessive-compulsive and related disorders · 2023Article
- Developmental aspects of fear generalization - A MEG study on neurocognitive correlates in adolescents versus adults.Developmental cognitive neuroscience · 2022Article
- The influences on happiness and life satisfaction of young people during COVID-19 pandemic: Evidence for positive youth development.Current psychology (New Brunswick, N.J.) · 2022Article
- Early Safety Discrimination Under Uncertainty in Trait Anxiety: An Event-Related Potential Study.Frontiers in human neuroscience · 2022Article
- Absence Makes the Mind Grow Fonder: Reconceptualizing Studies of Safety Learning in Translational Research on Anxiety.Cognitive, affective & behavioral neuroscience · 2021Review
- Salient safety conditioning improves novel discrimination learning.Behavioural brain research · 2021Article
- Intolerance of uncertainty and threat generalization: A replication and extension.Psychophysiology · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Attending to stimuli that share perceptual similarity to learned threats is an adaptive strategy. However, prolonged threat generalization to cues signalling safety is considered a core feature of pathological anxiety. One potential factor that may sustain over-generalization is sensitivity to future threat uncertainty. To assess the extent to which Intolerance of Uncertainty (IU) predicts threat generalization, we recorded skin conductance in 54 healthy participants during an associative learning paradigm, where threat and safety cues varied in perceptual similarity. Lower IU was associated with stronger discrimination between threat and safety cues during acquisition and extinction. Higher IU, however, was associated with generalized responding to threat and safety cues during acquisition, and delayed discrimination between threat and safety cues during extinction. These results were specific to IU, over and above other measures of anxious disposition. These findings highlight: (1) a critical role of uncertainty-based mechanisms in threat generalization, and (2) IU as a potential risk factor for anxiety disorder development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.