ArticleThe journal of headache and pain2016
Autonomous control of cardiovascular reactivity in patients with episodic and chronic forms of migraine.
Article in The journal of headache and pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reconceptualizing autonomic function testing in migraine: a systematic review and meta-analysis.The journal of headache and pain · 2024Pooled it
- Unraveling the Cross-Tissue Neuroimmune-Vascular Genetic Architecture of Migraine Using Integrated Multi-Omics, Single-Cell, and Spatial Transcriptomics: Prioritizing T-Cell Regulatory Networks and Peripheral Targets.International journal of molecular sciences · 2026Article
- Heart rate variability and pain sensitivity in people with chronic shoulder pain during passive viewing of shoulder movement pictures.PloS one · 2026Article
- Episodic Migraine and POTS.Current pain and headache reports · 2023Review
- Reduced cardiovagal baroreflex sensitivity is associated with postural orthostatic tachycardia syndrome (POTS) and pain chronification in patients with headache.Frontiers in human neuroscience · 2023Article
- Impairment on Cardiovascular Autonomic Modulation in Women with Migraine.International journal of environmental research and public health · 2022Article
- Do catastrophizing and autonomic-reduced flexibility mediate pain outcomes in chronic headache?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- The Function of the Autonomic Nervous System in Asian Patients With Chronic Migraine.Frontiers in neuroscience · 2022Article
- Is there a causal relationship between stress and migraine? Current evidence and implications for management.The journal of headache and pain · 2021Review
- Heart Rate Variability Analysis in Episodic Migraine: A Cross-Sectional Study.Frontiers in neurology · 2021Article
- Ambulatory blood pressure abnormalities in children with migraine.Pediatric nephrology (Berlin, Germany) · 2020Article
- Low-frequency facial hemodynamic oscillations distinguish migraineurs from non-headache controls.Cephalalgia reports · 2019Article
- Body Mass Index and Primary Headache: A Hospital-Based Study in China.BioMed research international · 2019Article
- Novel capsaicin-induced parameters of microcirculation in migraine patients revealed by imaging photoplethysmography.The journal of headache and pain · 2018Article
- Migraine and Autonomic Dysfunction: Which Is the Horse and Which Is the Jockey?Current pain and headache reports · 2018Review
- Association between Body Mass Index and Migraine: A Survey of Adult Population in China.Behavioural neurology · 2018Article
- Novel contactless approach for assessment of venous occlusion plethysmography by video recordings at the green illumination.Scientific reports · 2017Article
- Parasympathetic Cholinergic and Neuropeptide Mechanisms of Migraine.Anesthesiology and pain medicine · 2017Review
- Accurate measurement of the pulse wave delay with imaging photoplethysmography.Biomedical optics express · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe autonomous cardiovascular control can contribute to progression of migraine. However, current data on cardiovascular reactivity in migraine, especially severe forms, are essentially contradictory. The main aim of this study was to compare the autonomous regulation of circulation in patients with episodic and chronic migraine and healthy subjects.
methodsSeventy three migraine patients (mean age 35 ± 10) including episodic migraine (51 patients, 4-14 headache days/months) and chronic migraine (22 patients, ≥15 headache days/month) along with age-match control (71 healthy voluntaries) were examined. The autonomic regulation of circulation was examined with the tilt-table test, a deep breathing and Valsalva Maneuver, handgrip test, cold-stress vasoconstriction, arterial baroreflex and blood pressure variability.
resultsThe changes in heart rate induced by deep breathing, Valsalva Maneuver, and blood pressure in tilt-table test in patients with migraine did not differ from the control group. In contrast, the values of cold-stress-vasoconstriction forearm blood-flow reactivity (p <0.001), the increase in diastolic blood pressure in handgrip test (p <0.001), mean blood pressure in the late stage of the second phase of Valsalva Maneuver (p <0.001) and blood pressure variability (p <0.005) were all higher in patients with migraine than in the control group.
conclusionThus, both episodic and chronic migraine are associated with significant disturbances in autonomous control resulting in enhanced vascular reactivity whereas the cardiac regulation remains largely unchanged.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.