ArticlePloS one2016
A Comprehensive Analysis of miRNA/isomiR Expression with Gender Difference.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Targetome profile of hsa-miR-93-5p is resistant to isoform formation in prostate adenocarcinoma.PeerJ · 2026Article
- Quantification of EV-associated miRNA in liquid biopsies for biomarker signature development.Extracellular vesicles and circulating nucleic acids · 2026Review
- Decoding microRNA arm switching: a key to evolutionary innovation and gene regulation.Cellular and molecular life sciences : CMLS · 2025Review
- Extracellular microvesicles/exosomes-magic bullets in horizontal transfer between cells of mitochondria and molecules regulating mitochondria activity.Stem cells (Dayton, Ohio) · 2025Review
- 5'-Isoforms of miR-1246 Have Distinct Targets and Stronger Functional Impact Compared with Canonical miR-1246 in Colorectal Cancer Cells In Vitro.International journal of molecular sciences · 2024Article
- Current challenges surrounding exosome treatments.Extracellular vesicle · 2023Article
- Benchmarking of bioinformatics tools for NGS-based microRNA profiling with RT-qPCR method.Functional & integrative genomics · 2023Article
- Circulating miR-19a-3p and miR-19b-3p characterize the human aging process and their isomiRs associate with healthy status at extreme ages.Aging cell · 2021Article
- Identification and Elucidation of the Protective isomiRs in Lung Cancer Patient Prognosis.Frontiers in genetics · 2021Article
- isomiRs-Hidden Soldiers in the miRNA Regulatory Army, and How to Find Them?Biomolecules · 2020Review
- Elevated exosomal secretion of miR-124-3p from spinal neurons positively associates with disease severity in ALS.Experimental neurology · 2020Article
- Single nucleotide alterations in MicroRNAs and human cancer-A not fully explored field.Non-coding RNA research · 2020Review
- Hsa-miR-584-5p as a novel candidate biomarker in Turkish men with severe coronary artery disease.Molecular biology reports · 2020Article
- Postprandial transfer of colostral extracellular vesicles and their protein and miRNA cargo in neonatal calves.PloS one · 2020Article
- Genetic and epigenetic sex-specific adaptations to endurance exercise.Epigenetics · 2019Review
- Bias-minimized quantification of microRNA reveals widespread alternative processing and 3' end modification.Nucleic acids research · 2019Article
- Opportunities for microRNAs in the Crowded Field of Cardiovascular Biomarkers.Annual review of pathology · 2019Review
- Modulation of miRNA expression in natural populations of A. thaliana along a wide altitudinal gradient of Indian Himalayas.Scientific reports · 2019Article
- Sex-Dependent Changes in miRNA Expression in the Bed Nucleus of the Stria Terminalis Following Stress.Frontiers in molecular neuroscience · 2019Article
- Circulating microRNA plasma profile in MuSK+ myasthenia gravis.Journal of neuroimmunology · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although microRNAs (miRNAs) have been widely studied as epigenetic regulation molecules, fewer studies focus on the gender difference at the miRNA and isomiR expression levels. In this study, we aim to understand the potential relationships between gender difference and miRNA/isomiR expression through a comprehensive analysis of small RNA-sequencing datasets based on different human diseases and tissues. Based on specific samples from males and females, we determined that some miRNAs may be diversely expressed between different tissues and genders. Thus, these miRNAs may exhibit inconsistent and even opposite expression between males and females. According to deregulated miRNA expression profiles, some dominantly expressed miRNA loci were selected to analyze isomiR expression patterns using rates of dominant isomiRs. In some miRNA loci, isomiRs showed statistical significance between tumor and normal samples and between males and females samples, suggesting that isomiR expression patterns are not always invariable but may vary between males and females, as well as among different tissues, tumors, and normal samples. The divergence implicates the fluctuation in the expression of miRNA and its detailed expression at the isomiR levels. The divergence also indicates that gender difference may be an important factor that affects the screening of disease-associated miRNAs and isomiRs. This study suggests that miRNA/isomiR expression and gender difference may be more complex than previously assumed and should be further studied according to specific samples from males or females.
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