SynthesisOncotarget2016
Quantitative assessment of preoperative serum thyrotropin level and thyroid cancer.
Synthesis in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Association between vitamin D deficiency and risk of thyroid cancer: a case-control study and a meta-analysis.Journal of endocrinological investigation · 2018Pooled it
- Diagnostic and predictive value of the hemoglobin-albumin-lymphocyte-platelet score in thyroid nodules: A retrospective analysis of 521 patients.Northern clinics of Istanbul · 2026Article
- Vitamin D deficiency and thyroid cancer: is there a true association? A prospective observational study.Annals of the Royal College of Surgeons of England · 2025Observational
- Diagnostic Challenges of Thyrotropin-Secreting Hypophyseal Macroadenoma Associated with Papillary Thyroid Carcinoma: Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2025Article
- Laboratory parameters-based logistic regression models for rapid screening of thyroid nodules.Gland surgery · 2024Article
- Review
- Can Routine Laboratory Tests Be Suggestive in Determining Suspicions of Malignancy in the Case of Thyroid Nodules?Medicina (Kaunas, Lithuania) · 2023Article
- Knowns and unknowns about congenital hypothyroidism: 2022 update.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2023Review
- The relationship between subclinical hypothyroidism and invasive papillary thyroid cancer.Frontiers in endocrinology · 2023Article
- The optimal extent of lymph node dissection in N1b papillary thyroid microcarcinoma based on clinicopathological factors and preoperative ultrasonography.Gland surgery · 2022Article
- Relationship Between Thyroid-Stimulating Hormone Level and Aggressive Pathological Features of Papillary Thyroid Cancer.Sisli Etfal Hastanesi tip bulteni · 2022Article
- Association between preoperative serum TSH and tumor status in patients with papillary thyroid microcarcinoma.Endocrine · 2021Article
- Mendelian randomization supports a causative effect of TSH on thyroid carcinoma.Endocrine-related cancer · 2020Article
- The AsSociation Between Type 2 Diabetes Mellitus, Hypothyroidism, and Thyroid Cancer.Acta clinica Croatica · 2020Article
- The Blood Biomarkers of Thyroid Cancer.Cancer management and research · 2020Review
- The Relationship of Clinicopathological Factors of the Tumor with Preoperative TSH Level in Papillary Thyroid Cancers.The Eurasian journal of medicine · 2019Article
- The increasing prevalence of chronic lymphocytic thyroiditis in papillary microcarcinoma.Reviews in endocrine & metabolic disorders · 2018Review
- Is serum TSH a biomarker of thyroid carcinoma in patients residing in a mildly iodine-deficient area?Endocrine · 2018Article
- Association between preoperative thyrotrophin and clinicopathological and aggressive features of papillary thyroid cancer.Endocrine · 2018Article
- Vascular endothelial growth factor G+405C polymorphism may contribute to the risk of developing papillary thyroid carcinoma.Journal of clinical laboratory analysis · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid stimulating hormone (TSH) is the major growth factor for thyrocytes, but the pathogenic role of serum TSH in thyroid cancer (TC) is unknown. The association between TSH level and the development of thyroid cancer has been widely evaluated recently. However, the results remain conflicting. To develop an understanding of the relationship between TSH exposure and thyroid cancer, a meta-analysis of 56 studies involving 20227 thyroid cancer cases and 50003 controls with benign thyroid nodule was performed. Overall, significantly increased TSH level was observed in thyroid cancer patients compared with controls (RoM: 1.44, 95% CI: 1.32-1.56, P < 10-5). The pooled analyses also revealed that higher serum TSH level were significantly associated with the size of TC nodule and malignancy as well as lymph node metastasis. Furthermore, significantly increased THS levels were observed preferentially for papillary thyroid cancer when stratified by histological type of tumors. However, the diagnostic value of TSH level for TC might be limited. These results suggest that higher serum TSH concentration is associated with an increased risk of thyroid cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.