ReviewCell metabolism2016
Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk.
Review in Cell metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05427721 (Thymol Administration Effects on Netrin-1 Serum Concentration on Obese Patients), which is not on this map. Cited by 552 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Thymol Administration Effects on Netrin-1 Serum Concentration on Obese Patients
Who cites it
552 citing papers in PubMed, 8 syntheses or guidelines pooled it, 1,001 citations in OpenAlex.
- Therapeutic potential of AdipoRon in cognitive, depressive, and anxiety disorders: a systematic review and meta-analysis.Molecular brain · 2026Pooled it
- The effect of resveratrol supplementation on anthropometric indices, adiponectin and leptin levels in individuals with overweight and obesity: a graded, systematic review and meta-analysis of randomized controlled trials.International journal of obesity (2005) · 2026Pooled it
- Divergent responses of adiponectin and leptin to exercise in women with overweight or obesity: a systematic review and meta-regression.Frontiers in physiology · 2026Pooled it
- Effect of Polyphenol Supplementation on Adiposity: A Systematic Review of Randomized Clinical Trials.Current nutrition reports · 2025Pooled it
- Acute and chronic effects of high-intensity interval training on selected exerkine secretion in health, disease, and aging: a systematic review.Frontiers in physiology · 2025Pooled it
- Is low birth weight associated with lower adiponectin levels? - A systematic review and meta-analysis.PloS one · 2025Pooled it
- A large-scale, observational study to investigate the current status of diabetes complication and their prevention in Japan: incidence/risk factors for malignancies during follow-up-JDCP study 11 (English version).Diabetology international · 2024Guideline
- Exploring the logic and conducting a comprehensive evaluation of AdipoRon-based adiponectin replacement therapy against hormone-related cancers-a systematic review.Naunyn-Schmiedeberg's archives of pharmacology · 2024Pooled it
- Impact of 16/8 time-restricted eating on body composition and lipolytic hormone regulation in female DanceSport dancers.Journal of the International Society of Sports Nutrition · 2025Trial
- Weight-independent amelioration of adipokine profile by enavogliflozin, a selective SGLT2 inhibitor, in patients with type 2 diabetes.Cardiovascular diabetology · 2025Trial
- Mechanisms of obesogenic adipocyte signaling in mouse 3T3-L1 cells in response to plasma from C57BL/6 mice exposed to traffic-generated emissions and high-fat diet.Toxicology reports · 2026Article
- Neuroendocrine regulation of adipose partitioning in polyendocrine metabolic ovarian syndrome: the gut-brain-adipose axis.Journal of endocrinological investigation · 2026Review
- Adipose Tissue Palmitoylation Cycling Mediates Insulin Resistance and Preservation of β-Cell Function in Mice.Diabetes · 2026Article
- Review
- Adipose-cartilage communication via EV-Mito-mtDNA signaling promotes osteoarthritis progression.Science advances · 2026Article
- Adipocyte-Derived Leptolin Enhances Energy Expenditure and Prevents Obesity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Adiponectin preserves follicles through ADIPOR1/ADIPOR2-driven fatty acid metabolism.Molecular metabolism · 2026Article
- The Gut-brain-adipose Axis in Ultra-processed Food and Obesity: A Mechanistic Synthesis and Its Implications for Food Classification.Current obesity reports · 2026Review
- Epoxy Clerodane Diterpene Attenuates the Differentiated Adipocyte Hypertrophy and Enhances Mitochondrial Metabolism.ChemistryOpen · 2026Article
- Integrative Multi-Omics Profiling of Dynamic Body Mass Index-Systolic Blood Pressure Trajectories in Obesity for Precision Risk Stratification of Heart Failure Subtypes.Biomedicines · 2026Article
492 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Metabolism research has made tremendous progress over the last several decades in establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and energy homeostasis. Operating at multiple levels of control, the adipocyte communicates with organ systems to adjust gene expression, glucoregulatory hormone exocytosis, enzymatic reactions, and nutrient flux to equilibrate the metabolic demands of a positive or negative energy balance. The identification of these mechanisms has great potential to identify novel targets for the treatment of diabetes and related metabolic disorders. Herein, we review the central role of the adipocyte in the maintenance of metabolic homeostasis, highlighting three critical mediators: adiponectin, leptin, and fatty acids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.