Evidence map›Paper›PMID 27166937›Full record

ArticleCell metabolism2016

Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis.

Shabnam Shalapour, Michael Karin

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Future of anti-PD-1/PD-L1 applications: Combinations with other therapeutic regimens.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2018
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shabnam ShalapourLaboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Michael KarinLaboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: karinoffice@ucsd.edu.
University of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new study has added loss of CD4(+) T cells caused by aberrant lipid metabolism to the list of mechanisms promoting nonalcoholic steatohepatitis progression to liver cancer (Ma et al., 2016). Exposure of CD4(+) T cells to free linoleic acid causes their ROS-mediated depletion, thereby favoring liver cancer growth.

Indexed as

AnimalsCarcinogenesisCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFatty AcidsLiverMice, TransgenicModels, BiologicalT-LymphocytesFatty Acids

Identifiers

PMID27166937
OpenAlexW2372810110

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.