ArticleBiophysical journal2016
Probing the Twisted Structure of Sickle Hemoglobin Fibers via Particle Simulations.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Computational identification of potential modulators of heme-regulated inhibitor (HRI) for pharmacological intervention against sickle cell disease.Research square · 2023Article
- Sulfated non-anticoagulant heparin derivative modifies intracellular hemoglobin, inhibits cell sickling in vitro, and prolongs survival of sickle cell mice under hypoxia.Haematologica · 2022Article
- Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Polymer-Peptide Conjugates Convert Amyloid into Protein Nanobundles through Fragmentation and Lateral Association.ACS applied nano materials · 2020Article
- Rational Drug Design of Peptide-Based Therapies for Sickle Cell Disease.Molecules (Basel, Switzerland) · 2019Review
- Dynamics of deformable straight and curved prolate capsules in simple shear flow.Physical review fluids · 2019Article
- Molecular insights into the irreversible mechanical behavior of sickle hemoglobin.Journal of biomolecular structure & dynamics · 2019Article
- Quantifying Shear-Induced Deformation and Detachment of Individual Adherent Sickle Red Blood Cells.Biophysical journal · 2019Article
- Synergistic Integration of Laboratory and Numerical Approaches in Studies of the Biomechanics of Diseased Red Blood Cells.Biosensors · 2018Review
- Mesoscopic Adaptive Resolution Scheme toward Understanding of Interactions between Sickle Cell Fibers.Biophysical journal · 2017Article
- Patient-specific modeling of individual sickle cell behavior under transient hypoxia.PLoS computational biology · 2017Article
- Computational Biomechanics of Human Red Blood Cells in Hematological Disorders.Journal of biomechanical engineering · 2017Review
- Biomechanics and biorheology of red blood cells in sickle cell anemia.Journal of biomechanics · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Polymerization of sickle hemoglobin (HbS) is the primary pathogenic event of sickle cell disease. For insight into the nature of the HbS polymer fiber formation, we develop a particle model-resembling a coarse-grained molecular model-constructed to match the intermolecular contacts between HbS molecules. We demonstrate that the particle model predicts the formation of HbS polymer fibers by attachment of monomers to rough fiber ends and the growth rate increases linearly with HbS concentration. We show that the characteristic 14-molecule fiber cross section is preserved during growth. We also correlate the asymmetry of the contact sites on the HbS molecular surface with the structure of the polymer fiber composed of seven helically twisted double strands. Finally, we show that the same asymmetry mediates the mechanical and structural properties of the HbS polymer fiber.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.