ArticleEnvironment international
Prenatal exposure to multiple pesticides is associated with auditory brainstem response at 9months in a cohort study of Chinese infants.
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12 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Review
- Characterization of furathiocarb metabolism in in-vitro human liver microsomes and recombinant cytochrome P450 enzymes.Toxicology reports · 2022Article
- The relationship between prenatal exposure to organophosphate insecticides and neurodevelopmental integrity of infants at 5-weeks of age.Frontiers in epidemiology · 2022Article
- Exploring the effects and mechanisms of organophosphorus pesticide exposure and hearing loss.Frontiers in public health · 2022Review
- The Influence of Chemical Contaminants on the Physicochemical Properties of Unifloral and Multifloral Honey.Foods (Basel, Switzerland) · 2021Article
- Sub-Saharan Africa total diet study in Benin, Cameroon, Mali and Nigeria: Pesticides occurrence in foods.Food chemistry: X · 2019Article
- Detection of Diazinon Residue in Honey and Honey Bee (Journal of arthropod-borne diseases · 2019Article
- A Quantitative Tandem Mass Spectrometry and Scaled-Down QuEChERS Approach for Simultaneous Analysis of Pesticide Multiresidues in Human Urine.Molecules (Basel, Switzerland) · 2019Article
- Statistical Methodology in Studies of Prenatal Exposure to Mixtures of Endocrine-Disrupting Chemicals: A Review of Existing Approaches and New Alternatives.Environmental health perspectives · 2019Review
- Prenatal organophosphate insecticide exposure and infant sensory function.International journal of hygiene and environmental health · 2018Article
- Pesticide Residues in Honey from the Major Honey Producing Forest Belts in Ghana.Journal of environmental and public health · 2017Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPesticides are associated with poorer neurodevelopmental outcomes, but little is known about the effects on sensory functioning.
methodsAuditory brainstem response (ABR) and pesticide data were available for 27 healthy, full-term 9-month-old infants participating in a larger study of early iron deficiency and neurodevelopment. Cord blood was analyzed by gas chromatography-mass spectrometry for levels of 20 common pesticides. The ABR forward-masking condition consisted of a click stimulus (masker) delivered via ear canal transducers followed by an identical stimulus delayed by 8, 16, or 64 milliseconds (ms). ABR peak latencies were evaluated as a function of masker-stimulus time interval. Shorter wave latencies reflect faster neural conduction, more mature auditory pathways, and greater degree of myelination. Linear regression models were used to evaluate associations between total number of pesticides detected and ABR outcomes. We considered an additive or synergistic effect of poor iron status by stratifying our analysis by newborn ferritin (based on median split).
resultsInfants in the sample were highly exposed to pesticides; a mean of 4.1 pesticides were detected (range 0-9). ABR Wave V latency and central conduction time (CCT) were associated with the number of pesticides detected in cord blood for the 64ms and non-masker conditions. A similar pattern seen for CCT from the 8ms and 16ms conditions, although statistical significance was not reached. Increased pesticide exposure was associated with longer latency. The relation between number of pesticides detected in cord blood and CCT depended on the infant's cord blood ferritin level. Specifically, the relation was present in the lower cord blood ferritin group but not the higher cord blood ferritin group.
conclusionsABR processing was slower in infants with greater prenatal pesticide exposure, indicating impaired neuromaturation. Infants with lower cord blood ferritin appeared to be more sensitive to the effects of prenatal pesticide exposure on ABR latency delay, suggesting an additive or multiplicative effect.
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