Evidence map›Paper›PMID 27166680›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016

The current economic burden of illness of osteoporosis in Canada.

R B Hopkins, N Burke, C Von Keyserlingk, W D Leslie, S N Morin, J D Adachi, A Papaioannou, L Bessette, J P Brown, L Pericleous and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05541432 (Finding the Optimal Resistance Training Intensity For Your Bones), which is not on this map. Cited by 61 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05541432 nacompletednot on this mapstarted 2022, after this paper: background citation

Finding the Optimal Resistance Training Intensity For Your Bones: A Randomized Controlled Trial (FORTIFY Bones)

TypeinterventionalSponsorUniversity of WaterlooRan2022 to 2026Enrolled324ConditionsOsteoporosis, OsteopeniaArmsSupervised strength training (group 1), Supervised strength training (group 2), Home exercise
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Clinical practice guideline for management of osteoporosis and fracture prevention in Canada: 2023 update.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023
    Guideline
  4. Pooled it
  5. Recommendations on screening for primary prevention of fragility fractures.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023
    Guideline
  6. Pooled it
  7. Performance of predictive tools to identify individuals at risk of non-traumatic fracture: a systematic review, meta-analysis, and meta-regression.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Pooled it
  8. Pooled it
  9. Complex interventions can increase osteoporosis investigations and treatment: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Pooled it
  10. Describing the resource utilisation and costs associated withvertebral fractures: the Build Better Bones with Exercise (B3E) Pilot Trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
    Trial
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  20. Costs of incident non-hip osteoporosis-related fractures in postmenopausal women from a payer perspective.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

R B HopkinsPrograms for Assessment of Technology in Health (PATH), St Joseph's Healthcare Hamilton, Hamilton, ON, Canada. hopkinr@mcmaster.ca.
N BurkePrograms for Assessment of Technology in Health (PATH), St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
C Von KeyserlingkPrograms for Assessment of Technology in Health (PATH), St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
W D LeslieDepartment of Medicine, University of Manitoba, Winnipeg, MB, Canada.
S N MorinDepartment of Medicine, McGill University, Montréal, QC, Canada.
J D AdachiDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
A PapaioannouDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
L BessetteDepartment of Medicine, Laval University, Quebec City, Canada.
J P BrownDepartment of Medicine, Laval University, Quebec City, Canada.
L PericleousAmgen Canada Inc., Mississauga, ON, Canada.
J TarridePrograms for Assessment of Technology in Health (PATH), St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.

Funding

CIHR 88225-1
6 · The paper itself

Abstract

unlabelledWe estimate the current burden of illness of osteoporosis in Canada is double ($4.6 billion) our previous estimates ($2.3 billion) due to improved data capture of the multiple encounters and services that accompany a fracture: emergency room, admissions to acute and step-down non-acute institutions, rehabilitation, home-assisted or long-term residency support.

introductionWe previously estimated the economic burden of illness of osteoporosis-attributable fractures in Canada for the year 2008 to be $2.3 billion in the base case and as much as $3.9 billion. The aim of this study is to update the estimate of the economic burden of illness for osteoporosis-attributable fractures for Canada based on newly available home care and long-term care (LTC) data.

methodsMultiple national databases were used for the fiscal-year ending March 31, 2011 (FY 2010/2011) for acute institutional care, emergency visits, day surgery, secondary admissions for rehabilitation, and complex continuing care, as well as national dispensing data for osteoporosis medications. Gaps in national data were supplemented by provincial and community survey data. Osteoporosis-attributable fractures for Canadians age 50+ were identified by ICD-10-CA codes. Costs were expressed in 2014 dollars.

resultsIn FY 2010/2011, the number of osteoporosis-attributable fractures was 131,443 resulting in 64,884 acute care admissions and 983,074 acute hospital days. Acute care costs were $1.5 billion, an 18 % increase since 2008. The cost of LTC was 33.4 times the previous estimate ($31 million versus $1.03 billion) because of improved data capture. The cost for rehabilitation and secondary admissions increased 3.4 fold, while drug costs decreased 19 %. The overall cost of osteoporosis was over $4.6 billion, an increase of 83 % from the 2008 estimate.

conclusionSince the 2008 estimate, new Canadian data on home care and LTC are available which provided a better estimate of the burden of osteoporosis in Canada. This suggests that our previous estimates were seriously underestimated.

Indexed as

Cost of IllnessHealth Care CostsAgedAged, 80 and overCanadaFemaleHumansMaleMiddle AgedOsteoporosisOsteoporotic FracturesBurden of illnessCanadaFracturesHealth economicsOsteoporosis

Identifiers

PMID27166680
PMCPMC5104559

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.