Evidence map›Paper›PMID 27166557›Full record

ArticleMucosal immunology2017

CD4

S M Coomes, Y Kannan, V S Pelly, L J Entwistle, R Guidi, J Perez-Lloret, N Nikolov, W Müller, M S Wilson

Registry-linked trialOpen access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Mucosal immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04802616 (The Effect of Immunostimulation With Polyvalent Mechanical Bacterial Lysate on Changes in the Concentration of iNKT Cells in Children With Allergic Rhinitis.), which is not on this map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04802616 phase3completednot on this mapstarted 2021, after this paper: background citation

The Effect of Immunostimulation With Polyvalent Mechanical Bacterial Lysate on Changes in the Concentration of iNKT Cells in Children With Allergic Rhinitis.

TypeinterventionalSponsorMedical University of LublinRan2021 to 2021Enrolled80ConditionsAllergic Rhinitis Due to Grass PollenArmsIsmigen, Placebo
3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 182 citations in OpenAlex.

  1. Trial
  2. Article
  3. Preventive effect of heat-killed Lactiplantibacillus plantarum FM8 in an ovalbumin-induced food allergy murine model.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026
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  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. IL-21-dependent Ly6CCell death discovery · 2025
    Article
  13. Review
  14. Article
  15. T Regulatory Mechanisms in Airway and Interstitial Lung Disease.Seminars in respiratory and critical care medicine · 2025
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

S M CoomesThe Laboratory of Allergy and Anti-Helminth Immunity, Mill Hill Laboratory, The Francis Crick Institute, London, UK.
Y KannanThe Laboratory of Allergy and Anti-Helminth Immunity, Mill Hill Laboratory, The Francis Crick Institute, London, UK.
V S PellyThe Laboratory of Allergy and Anti-Helminth Immunity, Mill Hill Laboratory, The Francis Crick Institute, London, UK.
L J EntwistleThe Laboratory of Allergy and Anti-Helminth Immunity, Mill Hill Laboratory, The Francis Crick Institute, London, UK.
R GuidiThe Laboratory of Allergy and Anti-Helminth Immunity, Mill Hill Laboratory, The Francis Crick Institute, London, UK.
J Perez-LloretThe Laboratory of Allergy and Anti-Helminth Immunity, Mill Hill Laboratory, The Francis Crick Institute, London, UK.
N NikolovThe Laboratory of Allergy and Anti-Helminth Immunity, Mill Hill Laboratory, The Francis Crick Institute, London, UK.
W MüllerFaculty of Life Sciences, University of Manchester, Manchester, UK.
M S WilsonThe Laboratory of Allergy and Anti-Helminth Immunity, Mill Hill Laboratory, The Francis Crick Institute, London, UK.
The Francis Crick Institute · GBUniversity of Manchester · GB

Funding

Medical Research Council MC_UP_A253_1028
6 · The paper itself

Abstract

Interleukin-10 (IL-10) is an important regulatory cytokine required to control allergy and asthma. IL-10-mediated regulation of T cell-mediated responses was previously thought to occur indirectly via antigen-presenting cells. However, IL-10 can act directly on regulatory T cells and T helper type 17 (Th17) cells. In the context of allergy, it is therefore unclear whether IL-10 can directly regulate T helper type 2 (Th2) cells and whether this is an important regulatory axis during allergic responses. We sought to determine whether IL-10 signaling in CD4

Indexed as

Cell DifferentiationAnimalsAntigens, DermatophagoidesCells, CulturedCell SurvivalDisease Models, AnimalFemaleGranzymesHumansHypersensitivityImmune ToleranceInterleukin-10Lymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutAntigens, DermatophagoidesGranzymesInterleukin-10Receptors, Interleukin-10

Identifiers

PMID27166557
OpenAlexW2364195469

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.