ArticleeLife2016
Dynamic curvature regulation accounts for the symmetric and asymmetric beats of Chlamydomonas flagella.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 3 citations in OpenAlex.
- Embodied behavioural complexity in a ciliated microorganism.Nature communications · 2026Article
- Three-dimensional beating pattern of the ciliary tip in the live ciliate Tetrahymena.Journal of cell science · 2025Article
- The wavelength of the ciliary beat in Chlamydomonas saturates at long ciliary lengths.Biophysical journal · 2025Article
- Ciliary wavelength has its limits.Biophysical journal · 2025Article
- Quantification of flagellar gait changes with combined shape mode analysis and swimming simulations.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Article
- Intermediate light adaptation induces oscillatory phototaxis switching and pattern formation inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Active fluctuations of axoneme oscillations scale with number of dynein motors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The MBO2/FAP58 heterodimer stabilizes assembly of inner arm dyneinMolecular biology of the cell · 2024Article
- Effect of fluid elasticity on the emergence of oscillations in an active elastic filament.Journal of the Royal Society, Interface · 2024Article
- Evaluation of women's aging influence on sperm passage inside the fallopian tube using 3D dynamic mechanical modeling.Frontiers in bioengineering and biotechnology · 2024Article
- Methods and Measures for Investigating Microscale Motility.Integrative and comparative biology · 2023Review
- Human sperm rotate with a conserved direction during free swimming in four dimensions.Journal of cell science · 2023Article
- Active oscillations in microscale navigation.Animal cognition · 2023Review
- The reaction-diffusion basis of animated patterns in eukaryotic flagella.Nature communications · 2023Article
- Article
- Article
- Flagella-like beating of actin bundles driven by self-organized myosin waves.Nature physics · 2022Article
- A minimal model of elastic instabilities in biological filament bundles.Journal of the Royal Society, Interface · 2022Article
- Generation of ciliary beating by steady dynein activity: the effects of inter-filament coupling in multi-filament models.Journal of the Royal Society, Interface · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cilia and flagella are model systems for studying how mechanical forces control morphology. The periodic bending motion of cilia and flagella is thought to arise from mechanical feedback: dynein motors generate sliding forces that bend the flagellum, and bending leads to deformations and stresses, which feed back and regulate the motors. Three alternative feedback mechanisms have been proposed: regulation by the sliding forces, regulation by the curvature of the flagellum, and regulation by the normal forces that deform the cross-section of the flagellum. In this work, we combined theoretical and experimental approaches to show that the curvature control mechanism is the one that accords best with the bending waveforms of Chlamydomonas flagella. We make the surprising prediction that the motors respond to the time derivative of curvature, rather than curvature itself, hinting at an adaptation mechanism controlling the flagellar beat.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.