ArticleNucleic acids research2016
Synergistic activation of Arg1 gene by retinoic acid and IL-4 involves chromatin remodeling for transcription initiation and elongation coupling.
Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review).International journal of molecular medicine · 2026Review
- Beyond Antagonism: IL-4 Exploits TNF signaling to Shape Its Gene Expression Signature in Monocytes and Macrophages.bioRxiv : the preprint server for biology · 2025Article
- Intrinsic retinoic acid synthesis is required for oligodendrocyte progenitor expansion during CNS remyelination.Frontiers in cellular neuroscience · 2025Article
- QTL Mapping-Based Identification of Visceral White-Nodules Disease Resistance Genes inInternational journal of molecular sciences · 2024Article
- MicroRNA expression signature as a biomarker in the diagnosis of nodal T-cell lymphomas.Cancer cell international · 2024Article
- Functional characterization of interleukin 4 and retinoic acid signaling crosstalk during alternative macrophage activation.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2023Article
- Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors.Cell reports · 2021Article
- Epigenetic regulation of cellular functions in wound healing.Experimental dermatology · 2021Review
- New Therapeutic Tools to Shape Monocyte Functional Phenotypes in Leishmaniasis.Frontiers in immunology · 2021Review
- Potentiation of IL-4 Signaling by Retinoic Acid in Intestinal Epithelial Cells and Macrophages-Mechanisms and Targets.Frontiers in immunology · 2020Article
- DJ-1 Regulates Microglial Polarization Through P62-Mediated TRAF6/IRF5 Signaling in Cerebral Ischemia-Reperfusion.Frontiers in cell and developmental biology · 2020Article
- Glyburide and retinoic acid synergize to promote wound healing by anti-inflammation and RIP140 degradation.Scientific reports · 2018Article
- The Oncogenic Role of ARG1 in Progression and Metastasis of Hepatocellular Carcinoma.BioMed research international · 2018Article
- Macrophages are targets of retinoic acid signaling during the wound-healing process after thulium laser resection of the prostate.Oncotarget · 2017Article
- The role of prostate tumor overexpressed 1 in cancer progression.Oncotarget · 2017Review
- All-Frontiers in immunology · 2017Article
- Anti-Inflammatory Strategy for M2 Microglial Polarization Using Retinoic Acid-Loaded Nanoparticles.Mediators of inflammation · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
All-trans Retinoic acid (RA) and its derivatives are potent therapeutics for immunological functions including wound repair. However, the molecular mechanism of RA modulation in innate immunity is poorly understood, especially in macrophages. We found that topical application of RA significantly improves wound healing and that RA and IL-4 synergistically activate Arg1, a critical gene for tissue repair, in M2 polarized macrophages. This involves feed forward regulation of Raldh2, a rate-limiting enzyme for RA biosynthesis, and requires Med25 to coordinate RAR, STAT6 and chromatin remodeler, Brg1 to remodel the +1 nucleosome of Arg1 for transcription initiation. By recruiting elongation factor TFIIS, Med25 also facilitates transcriptional initiation-elongation coupling. This study uncovers synergistic activation of Arg1 by RA and IL-4 in M2 macrophages that involves feed forward regulation of RA synthesis and dual functions of Med25 in nucleosome remodeling and transcription initiation-elongation coupling that underlies robust modulatory activity of RA in innate immunity.
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