Evidence map›Paper›PMID 27166251›Full record

ArticleCirculation research2016

Proton Pump Inhibitors Accelerate Endothelial Senescence.

Gautham Yepuri, Roman Sukhovershin, Timo Z Nazari-Shafti, Michael Petrascheck, Yohannes T Ghebre, John P Cooke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 7 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 7 syntheses or guidelines pooled it, 147 citations in OpenAlex.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Gautham YepuriFrom the Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, TX (G.Y., R.S., T.Z.N-.S., J.P.C.); Department of Chemical Physiology, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (M.P.); and Department of Radiation Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, TX (Y.T.G.).
Roman SukhovershinFrom the Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, TX (G.Y., R.S., T.Z.N-.S., J.P.C.); Department of Chemical Physiology, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (M.P.); and Department of Radiation Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, TX (Y.T.G.).
Timo Z Nazari-ShaftiFrom the Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, TX (G.Y., R.S., T.Z.N-.S., J.P.C.); Department of Chemical Physiology, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (M.P.); and Department of Radiation Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, TX (Y.T.G.).
Michael PetrascheckFrom the Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, TX (G.Y., R.S., T.Z.N-.S., J.P.C.); Department of Chemical Physiology, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (M.P.); and Department of Radiation Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, TX (Y.T.G.).
Yohannes T GhebreFrom the Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, TX (G.Y., R.S., T.Z.N-.S., J.P.C.); Department of Chemical Physiology, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (M.P.); and Department of Radiation Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, TX (Y.T.G.).
John P CookeFrom the Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, TX (G.Y., R.S., T.Z.N-.S., J.P.C.); Department of Chemical Physiology, Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA (M.P.); and Department of Radiation Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, TX (Y.T.G.). jpcooke@houstonmethodist.org.
Scripps Research Institute · US

Funding

Basic and Translational Research iPSC-based hematologic and vascular therapiesU01HL100397 · NHLBI · STANFORD UNIVERSITY · PI COOKE, JOHN P · 2009 to 2015
$7.4M
DDAH As a Novel Target in Pulmonary FibrosisK01HL118683 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI GHEBRE, YOHANNES T · 2013 to 2017
$682k
NHLBI NIH HHS K01 HL118683NHLBI NIH HHS U01 HL100397
6 · The paper itself

Abstract

rationaleProton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which are now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal, and neurological morbidity.

objectiveTo study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI-induced vascular dysfunction. METHODS AND

resultsChronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length.

conclusionsOur data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal, and neurological morbidity and mortality.

Indexed as

Cell LineCellular SenescenceEndothelial CellsHumansProton Pump InhibitorsProton Pump Inhibitorsagingcardiovascular diseasesproteostasis deficienciesproton pump inhibitors

Identifiers

PMID27166251
PMCPMC4902745
OpenAlexW2367244125

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.