ArticleThe American journal of gastroenterology2016
Hospital Volume and Survival After Hepatocellular Carcinoma Diagnosis.
Article in The American journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Racial and Ethnic Disparities in Hepatocellular Carcinoma Treatment Receipt in the United States: A Systematic Review and Meta-Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Pooled it
- Multidisciplinary care for patients with HCC: a systematic review and meta-analysis.Hepatology communications · 2023Pooled it
- Modality-Specific and Multilevel Barriers to Curative Treatment for Early-Stage Hepatocellular Carcinoma.Liver cancer · 2026Article
- Advances in Locoregional and Systemic Treatments for Hepatocellular Carcinoma.Gastroenterology · 2025Review
- Achieving textbook outcome in liver resection for hepatocellular carcinoma: malnutrition's pivotal role.Langenbeck's archives of surgery · 2025Article
- Hepatocellular Carcinoma Screening in a Contemporary Cohort of At-Risk Patients.JAMA network open · 2024Article
- Hepatocellular Carcinoma Surveillance Patterns and Outcomes in Patients With Cirrhosis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Article
- Association of Textbook Outcome and Hospital Volume with Long-Term Survival Following Resection for Hepatocellular Carcinoma: What Matters More?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- Article
- The Impact of Medicaid Expansion on Early-Stage Hepatocellular Carcinoma Care.Annals of surgical oncology · 2023Article
- Facility Volume Thresholds for Optimization of Short- and Long-Term Outcomes in Patients Undergoing Hepatectomy for Primary Liver Tumors.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- Trends in hepatocellular carcinoma in Louisiana, 2005-2015.Dialogues in health · 2022Article
- Regional Differences in Admissions and Treatment Outcomes for Hepatocellular Carcinoma Patients in Thailand.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Therapeutic Underuse and Delay in Hepatocellular Carcinoma: Prevalence, Associated Factors, and Clinical Impact.Hepatology communications · 2022Article
- MRI-Based Radiomics: Nomograms predicting the short-term response after transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma patients with diameter less than 5 cm.Abdominal radiology (New York) · 2021Article
- Benefits of Local Treatment Including External Radiotherapy for Hepatocellular Carcinoma with Portal Invasion.Biology · 2021Article
- Medicare/Medicaid Insurance, Rurality, and Black Race Associated With Provision of Hepatocellular Carcinoma Treatment and Survival.Journal of the National Comprehensive Cancer Network : JNCCN · 2021Article
- A Novel Four-Gene Signature as a Potential Prognostic Biomarker for Hepatocellular Carcinoma.Journal of oncology · 2021Article
- Liver Cancer Survival: A Real World Observation of 45 Years with 32,556 Cases.Journal of hepatocellular carcinoma · 2021Article
- Is hepatocellular carcinoma surveillance in high-risk populations effective?Hepatic oncology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe association between hospital volume and outcome following high-risk low volume cancer surgery is well documented. However, this association is not well understood in cancer patients undergoing non-surgical therapies. We explored this association in a cohort of newly diagnosed patients with hepatocellular carcinoma (HCC).
methodsData from the 2000 through 2011 in Texas Cancer Registry were used to study adults with newly diagnosed HCC (17,231 patients from 322 hospitals). Hospital volume was stratified into low and high volume using Contal's outcome-based method. A multivariable Cox regression with shared frailty was used to evaluate the association between hospital volume and overall survival. The relationship between treatment modality and hospital volume was explored using mixed effects logistic regression.
resultsThe majority (61%) of HCC patients were seen in 21 high-volume hospitals. An annual hospital volume cutoff point of 24 patients was determined to stratify between high- and low-volume hospitals. Patients at high-volume hospitals presented more commonly with localized disease (56 vs. 50%, P<0.01) and were more likely to receive curative therapies including surgical resection, liver transplantation, or ablation (22 vs. 12%, P<0.01). High-volume hospitals were significantly associated with improved survival (HR=0.96, 95% CI=0.94-0.98). In multivariable analysis, hospital volume was associated with increased overall treatment utilization (OR=1.3, 95% CI=1.2-1.4).
conclusionsHospital volume is associated with improved overall survival, particularly in localized HCC. Improved survival may be mediated by increased utilization of treatments in high HCC volume hospitals.
Indexed as
Identifiers
27166130What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.