ArticleScientific reports2016
Gut microbiota composition and Clostridium difficile infection in hospitalized elderly individuals: a metagenomic study.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 1 of them a synthesis that pooled it.
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Who cites it
135 citing papers in PubMed, 1 synthesis or guideline pooled it, 222 citations in OpenAlex.
- Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review.Clinical interventions in aging · 2018Pooled it
- Association of metformin administration with gut microbiome dysbiosis in healthy volunteers.PloS one · 2018Trial
- Gut microbiome dynamics in acute infectious diarrhea: A conceptual framework from acute dysbiosis toward precision restoration (Review).Experimental and therapeutic medicine · 2026Review
- The gut microbiome and allograft outcomes: implications for heart transplantation.The Journal of clinical investigation · 2026Review
- Gut microbiota and aging: current understanding and future perspectives.Molecular biomedicine · 2026Review
- High-resolution metabolomic analysis of stool reveals expanded biomarkers ofMicrobiology spectrum · 2026Article
- Emerging Therapeutic Approaches for Modulating the Intestinal Microbiota.Pharmaceutics · 2026Review
- Metagenomic analysis reveals distinct patterns of gut microbiota features with diversified functions inGut microbes · 2025Article
- Longitudinal Gut Microbiome Changes Associated with Transitions fromMicroorganisms · 2025Article
- Rational Design of Live Biotherapeutic Products for the Prevention of Clostridioides difficile Infection.The Journal of infectious diseases · 2025Article
- Antibiotic-perturbed microbiota and the role of probiotics.Nature reviews. Gastroenterology & hepatology · 2025Review
- Evaluating the Efficacy of Secondary Metabolites in Antibiotic-Induced Dysbiosis: A Narrative Review of Preclinical Studies.Antibiotics (Basel, Switzerland) · 2025Review
- Exploring microbiome shifts across taxonomic and ecological groups of birds at a key stopover site in Punjab, Pakistan.Current research in microbial sciences · 2025Article
- Can Gut Microbiota Analysis RevealMicroorganisms · 2024Article
- Gut microbiota of children with autism spectrum disorder and healthy siblings: A comparative study.Experimental and therapeutic medicine · 2024Article
- Causal role of the gut microbiome in certain human diseases: a narrative review.eGastroenterology · 2024Review
- Metapresence: a tool for accurate species detection in metagenomics based on the genome-wide distribution of mapping reads.mSystems · 2024Article
- Impact of cryoprotective agents on human gut microbes and in vitro stabilized artificial gut microbiota communities.Microbial biotechnology · 2024Article
- Rational Design of Live Biotherapeutic Products for the Prevention ofbioRxiv : the preprint server for biology · 2024Article
- The interaction between Mediterranean diet and intestinal microbiome: relevance for preventive strategies against frailty in older individuals.Aging clinical and experimental research · 2024Review
75 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiota composition of elderly hospitalized patients with Clostridium difficile infection (CDI) exposed to previous antibiotic treatment is still poorly investigated. The aim of this study was to compare the microbiota composition by means of 16S rRNA microbial profiling among three groups of hospitalized elderly patients (age ≥ 65) under standard diet including 25 CDI-positive (CDI group), 29 CDI-negative exposed to antibiotic treatment (AB+ group) and 30 CDI-negative subjects not on antibiotic treatment (AB- group). The functional properties of the gut microbiomes of CDI-positive vs CDI-negative subjects were also assessed by shotgun metagenomics. A significantly lower microbial diversity was detected in CDI samples, whose microbiomes clustered separately from CDI-negative specimens. CDI was associated with a significant under-representation of gut commensals with putative protective functionalities, including Bacteroides, Alistipes, Lachnospira and Barnesiella, and over-representation of opportunistic pathogens. These findings were confirmed by functional shotgun metagenomics analyses, including an in-depth profiling of the Peptostreptococcaceae family. In CDI-negative patients, antibiotic treatment was associated with significant depletion of few commensals like Alistipes, but not with a reduction in species richness. A better understanding of the correlations between CDI and the microbiota in high-risk elderly subjects may contribute to identify therapeutic targets for CDI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.