Evidence map›Paper›PMID 27165730›Full record

ArticleBMC cardiovascular disorders2016

Factors associated with parasympathetic activation following exercise in patients with rheumatoid arthritis: a cross-sectional study.

Ahmad Osailan, George S Metsios, Peter C Rouse, Nikos Ntoumanis, Joan L Duda, George D Kitas, Jet J C S Veldhuijzen van Zanten

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Ahmad OsailanSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, B15 2TT, UK. axo269@bham.ac.uk.
George S MetsiosDepartment of Rheumatology, Dudley Group NHS Foundation Trust, Dudley, UK.
Peter C RouseSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Nikos NtoumanisSchool of Psychology & Speech Pathology, Curtin University, Perth, Australia.
Joan L DudaSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
George D KitasSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Jet J C S Veldhuijzen van ZantenSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Dudley Group NHS Foundation Trust · GBUniversity of Birmingham · GBCurtin University · AUUniversity of Bath · GBUniversity of Wolverhampton · GB

Funding

Medical Research Council G0802121
6 · The paper itself

Abstract

backgroundPatients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease (CVD) with poor parasympathetic function being implicated as an underlying factor. Factors related to parasympathetic function, commonly assessed by heart rate recovery (HRR) following maximal exercise, are currently not known in RA. We aimed to explore the association between HRR with CVD risk factors, inflammatory markers, and wellbeing in patients with RA.

methodsNinety-six RA patients (54.4 ± 12.6 years, 68 % women) completed a treadmill exercise test, during which heart rate (HR) was monitored. HRR1 and HRR2 were defined as the absolute change from HR peak to HRR 1 min post HR peak and 2 min post HR peak, respectively. Cardiorespiratory fitness, CVD risk factors, and serological markers of inflammation were measured in all patients. The Framingham Risk Score (FRS) was used as an assessment of global risk for CVD events, and wellbeing was assessed by questionnaires.

resultsMean HRR1 and HRR2 were 29.1 ± 13.2 bpm and 46.4 ± 15.3 bpm, respectively. CVD risk factors as well as most inflammatory markers and measures of wellbeing were inversely correlated with HRR1 and HRR2. Multivariate regression analyses revealed that 27.9 % of the variance in HRR1 and 37.9 % of the variance in HRR2 was explained collectively by CVD risk factors, measures of inflammation, and wellbeing (p = 0.009, p = 0.001 respectively), however no individual measure was independently associated with HRR1 or HRR2.

conclusionParasympathetic activation was associated with overall CVD risk, arthritis-related burden and wellbeing in patients with RA.

trial registration[Exercise, cardiovascular disease and rheumatoid arthritis, ISRCTN04121489 ].

Indexed as

ExerciseHeart RateAdultAgedArthritis, RheumatoidBiomarkersCost of IllnessCross-Sectional StudiesExercise TestExercise ToleranceFemaleHealth StatusHeartHumansInflammation MediatorsLinear ModelsBiomarkersInflammation MediatorsAutonomic functionCardiovascular riskExercise testingParasympathetic functionRheumatoid arthritis

Identifiers

PMID27165730
PMCPMC4862092
OpenAlexW2345684679

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.