Observational studyCirculation. Cardiovascular imaging2016
Prognostic Value of Coronary Artery Calcium Scoring in Addition to Single-Photon Emission Computed Tomographic Myocardial Perfusion Imaging in Symptomatic Patients.
Observational study in Circulation. Cardiovascular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Fully automated deep learning powered calcium scoring in patients undergoing myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Trial
- Hidden risk in normal myocardial perfusion scans: AI-detected proximal coronary calcium on CT attenuation maps improves prognosis.European journal of nuclear medicine and molecular imaging · 2026Article
- Patient-centric performance and interpretation of positron emission tomography /computed tomography myocardial perfusion imaging: a clinical consensus statement of the European Association of Cardiovascular Imaging of the European Society of Cardiology.European heart journal. Imaging methods and practice · 2026Review
- Integrating perfusion with AI-derived coronary calcium on CT attenuation scans to improve selection of low-risk studies for stress-only SPECT myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025Article
- Coronary artery calcium measurement on attenuation correction computed tomography using artificial intelligence: correlation with coronary flow capacity and prognosis.European journal of nuclear medicine and molecular imaging · 2025Article
- Patient centric performance and interpretation of SPECT and SPECT/CT myocardial perfusion imaging: a clinical consensus statement of the European Association of Cardiovascular Imaging of the ESC.European heart journal. Imaging methods and practice · 2025Review
- Reassessing the Role of Ischemia Imaging: Insights from the ISCHEMIA Trial.Nuclear medicine and molecular imaging · 2024Review
- The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0).Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- Automated vessel-specific coronary artery calcification quantification with deep learning in a large multi-centre registry.European heart journal. Cardiovascular Imaging · 2024Article
- Comparison of the prognostic value between quantification and visual estimation of coronary calcification from attenuation CT in patients undergoing SPECT myocardial perfusion imaging.The international journal of cardiovascular imaging · 2024Article
- Combined evaluation of CAC score and myocardial perfusion imaging in patients at risk of cardiovascular disease: where are we and what do the data say.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- In 2023 PET myocardial perfusion imaging is preferred to invasive coronary angiography for the initial work-up of a symptomatic patient with a high coronary artery calcium score.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Hybrid nuclear/CT cardiac imaging: Pros cons and the future.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Making fair comparisons: The potency and necessity of combining myocardial perfusion imaging and CAC scanning.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Coronary Calcium Predicts All-Cause Mortality in Suspected Acute Aortic Syndrome.Radiology. Cardiothoracic imaging · 2023Article
- The impact of coronary calcium score as an addition to myocardial perfusion imaging in altering clinical management (ICCAMPA trial).Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Deep Learning of Coronary Calcium Scores From PET/CT Attenuation Maps Accurately Predicts Adverse Cardiovascular Events.JACC. Cardiovascular imaging · 2023Article
- Transient ischaemic dilation ratio thresholds in patients with zero coronary calcium score undergoing exercise or dipyridamole stress SPECT myocardial perfusion imaging using a cadmium-zinc-telluride camera.European heart journal. Imaging methods and practice · 2023Article
- Deep Learning Coronary Artery Calcium Scores from SPECT/CT Attenuation Maps Improve Prediction of Major Adverse Cardiac Events.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Integration of coronary artery calcium scoring from CT attenuation scans by machine learning improves prediction of adverse cardiovascular events in patients undergoing SPECT/CT myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prognostic value of coronary artery calcium (CAC) scoring on top of myocardial perfusion imaging with single-photon emission computed tomography (SPECT) in patients suspected for coronary artery disease is not well established. METHODS AND
resultsFour thousand eight hundred ninety-seven symptomatic patients without a history of coronary artery disease referred for SPECT and CAC scoring were included. Major adverse cardiac events (MACEs) were defined as late revascularization (>90 days after scanning), nonfatal myocardial infarction, and all-cause mortality. The frequency of abnormal SPECT increased with higher CAC scores, from 12% in patients with CAC scores of 0 to 19%, 32%, 37%, and 50% among those with CAC scores 1 to 99, 100 to 399, 400 to 999, and ≥1000, respectively (P<0.001). During a median follow-up of 940 days (25th to 75th percentile, 581-1377), a total of 278 MACEs were observed. Overall incidence of MACE was 2.3% per year. A stepwise increase of MACE was present with increasing CAC scores, both in patients with normal SPECT (annual event rate CAC score 0: 0.6%; CAC score ≥1000: 5.5%) and abnormal SPECT (annual event rate CAC score 0: 0.4%; CAC score ≥1000: 7.6%). After multivariate analysis, both SPECT and CAC score were independent predictors of MACE (CAC score ≥1000: hazard ratio, 7.7; P<0.001 and large perfusion defect on SPECT: hazard ratio, 3.7; P<0.001).
conclusionsCAC score and SPECT are independent predictors of MACE in patients suspected for coronary artery disease. Our findings strongly support performing a CAC score in addition to SPECT in symptomatic patients to better define the risk of events during follow-up.
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