Evidence map›Paper›PMID 27165681›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2016

MERS versus Standard Surgical Approaches for Porcine Vocal Fold Scarring with Adipose Stem Cell Constructs.

Joo Hyun Woo, Suzanne N King, Henry Hoffman, Seth Dailey, Sarah Wang, Michael B Christensen, Susan L Thibeault

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Preclinical Vocal Fold and Airway Injury Models: A Scoping Review.Laryngoscope investigative otolaryngology · 2025
    Review
  2. Reinke's edema management and voice outcomes.Laryngoscope investigative otolaryngology · 2022
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joo Hyun WooDepartment of Otorhinolaryngology-Head and Neck Surgery, Gil Medical Center, Gachon University, Incheon, Korea.
Suzanne N KingDepartment of Neurological Surgery, University of Louisville, Louisville, Kentucky, USA.
Henry HoffmanDepartment of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA.
Seth DaileyDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Sarah WangDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Michael B ChristensenNational Center for Voice and Speech, University of Utah, Salt Lake City, Utah, USA.
Susan L ThibeaultDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA thibeaul@surgery.wisc.edu.

Funding

Engineering the Vocal Fold MucosaR01DC004336 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI Susan Lynn Thibeault · 2000 to 2026
$14.6M
University of Wisconsin Voice Research Training Program (T32)T32DC009401 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI Susan Lynn Thibeault · 2009 to 2026
$6.3M
Macrophage And Fibroblast Modulation Toward Chronic Vocal Fold Scar RestorationR01DC013508 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI HAHN, MARIAH S, THIBEAULT, SUSAN LYNN · 2014 to 2018
$2.5M
NIDCD NIH HHS R01 DC004336NIDCD NIH HHS R01 DC013508NIDCD NIH HHS T32 DC009401
6 · The paper itself

Abstract

objectiveCells, scaffold, and surgical approaches are important for regeneration of the lamina propria of the scarred vocal fold (VF). Microendoscopy of Reinke's space (MERS) is a surgical approach used to access the lamina propria. The present study evaluated MERS in the treatment of VF scarring as compared with standardized approaches for the treatment of VF scarring with adipose stem cell constructs. STUDY

designAnimal study.

settingAcademic center. SUBJECTS AND

methodsVF injury was performed bilaterally to induce scarring in 20 pigs. Eight weeks after injury, pigs were classified into no treatment, minithyrotomy, VF injection, VF incision/dissection, and MERS. All groups (except control) were implanted with adipose stem cell and hyaluronan. Four weeks after treatment, histology for collagen, hyaluronan, and fibronectin; mRNA expression for α-smooth muscle actin, tumor growth factor β1, collagen 1α1, collagen 3α1, matrix metalloproteinase 2, basic fibroblast growth factor, and hepatocyte growth factor; and tissue rheology were evaluated.

resultsDifferences were measured among surgical approaches for protein levels of collagen, hyaluronan, and fibronectin (P = .0133, P < .0001, and P = .0025, respectively). Fibroblast growth factor, collagen 1α1, and matrix metalloproteinase 2 transcript levels were different among treatment groups (P = .003, P = .0086, and P = .014, respectively), while no differences were measured for α-smooth muscle actin, tumor growth factor β1, hepatocyte growth factor, and collagen 3α1. Rheologically, significant differences were not measured between groups.

conclusionMERS is a promising surgical approach for the treatment of VF scarring, optimizing the placement of implanted biomaterials.

Indexed as

AnimalsBiomarkersCells, CulturedCicatrixDisease Models, AnimalFemaleFibrin Tissue AdhesiveHydrogelsImmunoenzyme TechniquesLaryngoscopyReal-Time Polymerase Chain ReactionStem Cell TransplantationSwineVocal CordsBiomarkersFibrin Tissue AdhesiveHydrogelsadipose tissue–derived stromal cellshydrogelReinke’s spacescarvocal fold

Identifiers

PMID27165681
PMCPMC7032050

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.