ArticleDevelopmental cell2016
The Molecular Basis of Radial Intercalation during Tissue Spreading in Early Development.
Article in Developmental cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Tissue flow acts as a guidance cue for immune cell polarization and directional migration.Nature cell biology · 2026Article
- Single-cell morphodynamics predict cell fate decisions during mucociliary epithelial differentiation.Molecular systems biology · 2026Article
- Sidekick2 facilitates multiciliated cell penetration through multicellular adherens junctions.bioRxiv : the preprint server for biology · 2026Article
- Single-cell morphodynamics predict cell fate decisions during mucociliary epithelial differentiation.bioRxiv : the preprint server for biology · 2025Article
- Differences in boundary behavior in the 3D vertex and Voronoi models.PLoS computational biology · 2024Article
- Multicellular rosettes link mesenchymal-epithelial transition to radial intercalation in the mouse axial mesoderm.Developmental cell · 2023Article
- How dynamic prestress governs the shape of living systems, from the subcellular to tissue scale.Interface focus · 2022Review
- Hydrocoel morphogenesis forming the pentaradial body plan in a sea cucumber, Apostichopus japonicus.Scientific reports · 2022Article
- Article
- A live-imaging protocol to track cell movement in theSTAR protocols · 2021Article
- Tubulin acetylation promotes penetrative capacity of cells undergoing radial intercalation.Cell reports · 2021Article
- More than a Pore: Nonlytic Antimicrobial Functions of Complement and Bacterial Strategies for Evasion.Microbiology and molecular biology reviews : MMBR · 2021Review
- Cell intercalation in a simple epithelium.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Convergent extension in the amphibian, Xenopus laevis.Current topics in developmental biology · 2020Review
- Morpholinos Do Not Elicit an Innate Immune Response during Early Xenopus Embryogenesis.Developmental cell · 2019Review
- Coming to Consensus: A Unifying Model Emerges for Convergent Extension.Developmental cell · 2018Review
- May the force be with you.eLife · 2018Article
- Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation.Developmental cell · 2018Article
- Article
- Regulation of gastrulation movements by emergent cell and tissue interactions.Current opinion in cell biology · 2017Review
Corrections and comments
- Commented on by
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Radial intercalation is a fundamental process responsible for the thinning of multilayered tissues during large-scale morphogenesis; however, its molecular mechanism has remained elusive. Using amphibian epiboly, the thinning and spreading of the animal hemisphere during gastrulation, here we provide evidence that radial intercalation is driven by chemotaxis of cells toward the external layer of the tissue. This role of chemotaxis in tissue spreading and thinning is unlike its typical role associated with large-distance directional movement of cells. We identify the chemoattractant as the complement component C3a, a factor normally linked with the immune system. The mechanism is explored by computational modeling and tested in vivo, ex vivo, and in vitro. This mechanism is robust against fluctuations of chemoattractant levels and expression patterns and explains expansion during epiboly. This study provides insight into the fundamental process of radial intercalation and could be applied to a wide range of morphogenetic events.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.