ArticleNature communications2016
Genomics reveals historic and contemporary transmission dynamics of a bacterial disease among wildlife and livestock.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 159 citations in OpenAlex.
- Brucellosis in wildlife in Africa: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Predicting disease spread from host movement data: Chronic wasting disease in North America as a case study.The Journal of animal ecology · 2026Article
- Climate-Sensitive Redistribution of Veterinary Parasites: An Attribution Framework for One Health Surveillance and Control.Biology · 2026Review
- Identification and Genome Phylogenetic Analysis of ThreeTransboundary and emerging diseases · 2026Article
- Global distribution and multidimensional risk assessment of brucellosis in humans, livestock, and wildlife.Frontiers in microbiology · 2026Article
- Infectious bacteria as biological warfare agents: mechanisms, epidemiological threats, and defense strategies.Frontiers in bioengineering and biotechnology · 2026Review
- Ebselen, a promising host-directed therapeutic option againstFrontiers in microbiology · 2026Article
- Genetic connectivity and admixture zones shape the spread of African swine fever in wild Boar populations in North-western Italy.Scientific reports · 2025Article
- Design of a Prospective Human-Animal Cohort Study to Evaluate the Role of Camels and Other Livestock Species in the Transmission ofInternational journal of environmental research and public health · 2025Article
- Cultural and behavioral drivers of zoonotic disease transmission and persistence among diverse pastoralist communities in East Africa.One health outlook · 2025Article
- Genome phylogenetic analysis of Brucella melitensis in Northwest China.BMC microbiology · 2025Article
- Brucellosis in cattle and buffalo in southern Italian provinces: trends in presence of territory-specific One Health measures.Frontiers in microbiology · 2025Article
- Origin and cross-species transmission of bat coronaviruses in China.Nature communications · 2024Article
- Molecular epidemiology of brucellosis in Asia: insights from genotyping analyses.Veterinary research communications · 2024Review
- Examining the molecular clock hypothesis for the contemporary evolution of the rabies virus.PLoS pathogens · 2024Article
- A scoping review on the epidemiology and public significance ofOne health (Amsterdam, Netherlands) · 2024Article
- vSNP: a SNP pipeline for the generation of transparent SNP matrices and phylogenetic trees from whole genome sequencing data sets.BMC genomics · 2024Article
- Brucellosis emergence in the Canadian Arctic.One health (Amsterdam, Netherlands) · 2024Article
- Wildlife-Livestock Host Community Maintains Simultaneous Epidemiologic Cycles ofVeterinary sciences · 2024Article
- Molecular Epidemiological Study of a Human Brucellosis Outbreak - Weihai City, Shandong Province, China, 2022.China CDC weekly · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whole-genome sequencing has provided fundamental insights into infectious disease epidemiology, but has rarely been used for examining transmission dynamics of a bacterial pathogen in wildlife. In the Greater Yellowstone Ecosystem (GYE), outbreaks of brucellosis have increased in cattle along with rising seroprevalence in elk. Here we use a genomic approach to examine Brucella abortus evolution, cross-species transmission and spatial spread in the GYE. We find that brucellosis was introduced into wildlife in this region at least five times. The diffusion rate varies among Brucella lineages (∼3 to 8 km per year) and over time. We also estimate 12 host transitions from bison to elk, and 5 from elk to bison. Our results support the notion that free-ranging elk are currently a self-sustaining brucellosis reservoir and the source of livestock infections, and that control measures in bison are unlikely to affect the dynamics of unrelated strains circulating in nearby elk populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.