ArticleScientific reports2016
Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 35 citations in OpenAlex.
- Aquaporins: a novel perspective in the treatment of lung diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Aquaporins in Allergic Response: A New Player.Clinical reviews in allergy & immunology · 2025Review
- Selective Blockade of Two Aquaporin Channels, AQP3 and AQP9, Impairs Human Leukocyte Migration.Cells · 2025Article
- Peroxiporins and Oxidative Stress: Promising Targets to Tackle Inflammation and Cancer.International journal of molecular sciences · 2024Review
- Aquaporins (AQPs) as a marker in the physiology of inflammation and its interaction studies with garcinol.Inflammopharmacology · 2024Article
- The Aquaporin 3 Polymorphism (rs17553719) Is Associated with Sepsis Survival and Correlated with IL-33 Secretion.International journal of molecular sciences · 2024Article
- In silico analysis of molecular mimicry between human aquaporin 3,F1000Research · 2024Article
- Important functions and molecular mechanisms of aquaporins family on respiratory diseases: potential translational values.Journal of Cancer · 2024Review
- Aquaporins: Potential Targets in Inflammatory Diseases.The Eurasian journal of medicine · 2023Article
- Integrative scATAC-seq and scRNA-seq analyses map thymic iNKT cell development and identify Cbfβ for its commitment.Cell discovery · 2023Article
- Inhibition of lincRNA-Cox2 alleviates apoptosis and inflammatory injury of lipopolysaccharide-stimulated human bronchial epithelial cells via the Nrf2/HO-1 axis.Journal of clinical biochemistry and nutrition · 2023Article
- Immunogenetics associated with severe coccidioidomycosis.JCI insight · 2022Article
- Anti-tumor effect of aquaporin 3 monoclonal antibody on syngeneic mouse tumor model.Translational oncology · 2022Article
- Localization of aquaglyceroporins in human and murine white adipose tissue.Histochemistry and cell biology · 2022Article
- Seawater immersion exacerbates the pathological changes caused by incisive corneal injury in rabbit eyes.Annals of translational medicine · 2022Article
- Differential modulation of lung aquaporins among other pathophysiological markers in acute (ClFrontiers in physiology · 2022Article
- Aquaporins in Immune Cells and Inflammation: New Targets for Drug Development.International journal of molecular sciences · 2021Review
- Role of Aquaporins in Inflammation-a Scientific Curation.Inflammation · 2020Review
- Genome‑wide analysis of DNA methylation and gene expression changes in an ovalbumin‑induced asthma mouse model.Molecular medicine reports · 2020Article
- Expression, Distribution and Role of Aquaporins in Various Rhinologic Conditions.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
Oxidative stress plays a pivotal role in the pathogenesis of asthma. Aquaporin-3 (AQP3) is a small transmembrane water/glycerol channel that may facilitate the membrane uptake of hydrogen peroxide (H2O2). Here we report that AQP3 potentiates ovalbumin (OVA)-induced murine asthma by mediating both chemokine production from alveolar macrophages and T cell trafficking. AQP3 deficient (AQP3(-/-)) mice exhibited significantly reduced airway inflammation compared to wild-type mice. Adoptive transfer experiments showed reduced airway eosinophilic inflammation in mice receiving OVA-sensitized splenocytes from AQP3(-/-) mice compared with wild-type mice after OVA challenge, consistently with fewer CD4(+) T cells from AQP3(-/-) mice migrating to the lung than from wild-type mice. Additionally, in vivo and vitro experiments indicated that AQP3 induced the production of some chemokines such as CCL24 and CCL22 through regulating the amount of cellular H2O2 in M2 polarized alveolar macrophages. These results imply a critical role of AQP3 in asthma, and AQP3 may be a novel therapeutic target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.