ArticleBMC pulmonary medicine2016
The temporal relationship between poor lung function and the risk of diabetes.
Article in BMC pulmonary medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Chronic obstructive pulmonary disease, lung function and risk of type 2 diabetes: a systematic review and meta-analysis of cohort studies.BMC pulmonary medicine · 2020Pooled it
- Association of lung function impairment with risk of incident diabetes in patients with obstructive sleep apnea: A prospective cohort study.Sleep & breathing = Schlaf & Atmung · 2026Article
- Association between body roundness index and lung function among U.S. adults.BMC public health · 2025Article
- Associations between life's essential 8 and preserved ratio impaired spirometry.Scientific reports · 2025Article
- Lifetime Body Mass Index Trajectories and Contrasting Lung Function Abnormalities in Mid-Adulthood: Data From the Tasmanian Longitudinal Health Study.Respirology (Carlton, Vic.) · 2025Article
- Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study.BMJ open respiratory research · 2025Article
- Rapid FEV1 decline and the effects of both FEV1 and FVC on cardiovascular disease: A UK biobank cohort analysis.BMC public health · 2024Article
- Restrictive Spirometric Pattern and Preserved Ratio Impaired Spirometry in a Population Aged 50-64 Years.Annals of the American Thoracic Society · 2024Article
- Causal relationship between type 2 diabetes and common respiratory system diseases: a two-sample Mendelian randomization analysis.Frontiers in medicine · 2024Article
- The negative association between weight-adjusted-waist index and lung functions: NHANES 2007-2012.PloS one · 2024Article
- COVID-19 and persistent symptoms: implications for polycystic ovary syndrome and its management.Frontiers in endocrinology · 2024Review
- Extrapulmonary Comorbidities Associated with Chronic Obstructive Pulmonary Disease: A Review.International journal of chronic obstructive pulmonary disease · 2024Review
- Can birth weight predict offspring's lung function in adult age? Evidence from two Swedish birth cohorts.Respiratory research · 2022Article
- Polygenic scores for low lung function and the future risk of adverse health outcomes.Cardiovascular diabetology · 2022Article
- Triglyceride-Glucose Index is a Risk Marker of Incident COPD Events in Women.International journal of chronic obstructive pulmonary disease · 2022Article
- Association between Lung Function and New-Onset Diabetes Mellitus in Healthy Individuals after a 6-Year Follow-up.Endocrinology and metabolism (Seoul, Korea) · 2021Article
- Low lung function, sudden cardiac death and non-fatal coronary events in the general population.BMJ open respiratory research · 2021Article
- Genetic correlation and causal relationships between cardio-metabolic traits and lung function impairment.Genome medicine · 2021Article
- Negative associations for fasting blood glucose, cholesterol and triglyceride levels with the development of giant cell arteritis.Rheumatology (Oxford, England) · 2020Article
- Low lung function and the risk of incident chronic kidney disease in the Malmö Preventive Project cohort.BMC nephrology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between impaired lung function and diabetes risk has been established in the past, however the temporal and causal relationships between the two remain unclear. We assessed the relationship between baseline FEV1 and FVC and risk of incident diabetes at different time intervals for participants in the Malmö Preventive Project cohort.
methodsBaseline lung function was assessed in 20,295 men and 7416 women during 1974-1992; mean age 43.4 ± 6.6 and 47.6 ± 7.8, respectively. Sex-specific quartiles of FEV1%predicted and FVC%predicted were created (Q4 = highest; reference). Follow-up time was divided into 10-year time intervals from baseline examination. Cox proportional hazards regression was used to assess the incidence of diabetes according to quartiles of FEV1 and FVC%predicted, after adjustments for baseline glucose and potential confounding factors.
resultsOver 37-years' follow-up there were 3753 and 993 incident diabetes events in men and women, respectively. When comparing FEV1%predicted in men (Q1 vs. Q4), the HR for diabetes was 1.64 (1.21-2.22) for events <10 years after baseline, 1.52 (1.27-1.81) for events 10-20 years after baseline, 1.39 (1.22-1.59) for events 20-30 years after baseline, and 1.46 (1.08-1.97) for events occurring >30 years after baseline. A broadly similar pattern was seen for FVC%predicted and for women.
conclusionsLow FEV1 precedes and significantly predicts future diabetes. This risk is still significant many years after the baseline FEV1 measurement in middle-aged men. These results suggest that there is a relationship between impaired lung function and diabetes risk beyond the effects of hyperglycemia on lung function.
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