Evidence map›Paper›PMID 27165051›Full record

ReviewReproduction (Cambridge, England)2016

Endometriosis: where are we and where are we going?

Alexis D Greene, Stephanie A Lang, Jessica A Kendziorski, Julie M Sroga-Rios, Thomas J Herzog, Katherine A Burns

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reproduction (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 2 pooled it
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 2 syntheses or guidelines pooled it, 183 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Patient-Centred Perspectives on Diagnostic Strategies for Endometriosis: A Qualitative Study.BJOG : an international journal of obstetrics and gynaecology · 2026
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alexis D GreeneDepartment of Obstetrics and GynecologyUniversity of Cincinnati Center for Reproductive Health, Cincinnati, Ohio, USA.
Stephanie A LangDepartment of Environmental HealthUniversity of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Jessica A KendziorskiDepartment of Environmental HealthUniversity of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Julie M Sroga-RiosDepartment of Obstetrics and GynecologyUniversity of Cincinnati Center for Reproductive Health, Cincinnati, Ohio, USA.
Thomas J HerzogDepartment of Obstetrics and GynecologyUniversity of Cincinnati Center for Reproductive Health, Cincinnati, Ohio, USA University of Cincinnati Cancer InstituteUniversity of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Katherine A BurnsDepartment of Environmental HealthUniversity of Cincinnati College of Medicine, Cincinnati, Ohio, USA Katherine.Burns@uc.edu.
University of Cincinnati Medical Center · USInstitute for Reproductive Health · USUniversity of Cincinnati · US

Funding

Endometriosis and Environmental Endocrine Disrupting Chemical ExposureR00ES021737 · NIEHS · UNIVERSITY OF CINCINNATI · PI BURNS, KATHERINE ANNE · 2015 to 2017
$737k
NIEHS NIH HHS R00 ES021737
6 · The paper itself

Abstract

Endometriosis currently affects ~5.5 million reproductive-aged women in the U.S. with symptoms such as painful periods (dysmenorrhea), chronic pelvic pain, pain with intercourse (dyspareunia), and infertility. It is defined as the presence of endometrial tissue outside the uterine cavity and is found predominately attached to sites within the peritoneal cavity. Diagnosis for endometriosis is solely made through surgery as no consistent biomarkers for disease diagnosis exist. There is no cure for endometriosis and treatments only target symptoms and not the underlying mechanism(s) of disease. The nature of individual predisposing factors or inherent defects in the endometrium, immune system, and/or peritoneal cavity of women with endometriosis remains unclear. The literature over the last 5 years (2010-2015) has advanced our critical knowledge related to hormones, hormone receptors, immune dysregulation, hormonal treatments, and the transformation of endometriosis to ovarian cancer. In this review, we cover the aforementioned topics with the goal of providing the reader an overview and related references for further study to highlight the progress made in endometriosis research, while concluding with critical areas of endometriosis research that are urgently needed.

Indexed as

EndometriosisFemaleHumans

Identifiers

PMID27165051
PMCPMC4958554
OpenAlexW2371764543

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.