Evidence map›Paper›PMID 27165013›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Pharmacological inhibition of mannose-binding lectin ameliorates neurobehavioral dysfunction following experimental traumatic brain injury.

Daiana De Blasio, Stefano Fumagalli, Luca Longhi, Franca Orsini, Alessandro Palmioli, Matteo Stravalaci, Gloria Vegliante, Elisa R Zanier, Anna Bernardi, Marco Gobbi and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Immune Response in Traumatic Brain Injury.Current neurology and neuroscience reports · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Non-Invasive Intranasal Delivery ofInternational journal of molecular sciences · 2023
    Article
  8. Tackling Neuroinflammation After Traumatic Brain Injury: Complement Inhibition as a Therapy for Secondary Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  9. Review
  10. Applications of mannose-binding lectins and mannan glycoconjugates in nanomedicine.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2022
    Review
  11. Article
  12. Article
  13. Aberrant Complement System Activation in Neurological Disorders.International journal of molecular sciences · 2021
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Poster Viewing Sessions PB01-B01 to PB03-V09.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Article
  20. Human brain trauma severity is associated with lectin complement pathway activation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Daiana De Blasio1 IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Stefano Fumagalli1 IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Luca Longhi3 Department of Anesthesia and Critical Care Medicine, Neurosurgical Intensive Care Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Franca Orsini1 IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Alessandro Palmioli4 Department of Chemistry, Università degli Studi di Milano, Milano, Italy.
Matteo Stravalaci1 IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Gloria Vegliante1 IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Elisa R Zanier1 IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Anna Bernardi4 Department of Chemistry, Università degli Studi di Milano, Milano, Italy.
Marco Gobbi1 IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Maria-Grazia De Simoni1 IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITMario Negri Institute for Pharmacological Research · ITUniversity of Milan · ITOspedale Papa Giovanni XXIII · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mannose-binding lectin is present in the contusion area of traumatic brain-injured patients and in that of traumatic brain-injured mice, where mannose-binding lectin-C exceeds mannose-binding lectin-A. The reduced susceptibility to traumatic brain injury of mannose-binding lectin double knock-out mice (mannose-binding lectin

Indexed as

AnimalsBrain Injuries, TraumaticDendrimersDisease Models, AnimalGlycosidesLigandsMaleMannoseMannose-Binding LectinMiceMice, KnockoutNeurogenesisProtein BindingRecovery of FunctionSensorimotor CortexDendrimersglycodendrimer 13.3GlycosidesLigandsMannoseMannose-Binding LectinMbl2 protein, mousebehavior (rodent)brain recoverybrain traumaInflammationmannose-binding lectin inhibitorneuroregeneration

Identifiers

PMID27165013
PMCPMC5363468
OpenAlexW2376749222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.