ReviewEuropean journal of nuclear medicine and molecular imaging2016
Clinical utility of F-18 FDG PET-CT in the initial evaluation of lung cancer.
Review in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- EarlyCDT Lung blood test for risk classification of solid pulmonary nodules: systematic review and economic evaluation.Health technology assessment (Winchester, England) · 2022Pooled it
- Lung Cancer Screening, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology.Journal of the National Comprehensive Cancer Network : JNCCN · 2018Guideline
- Preoperative CT-based artificial intelligence-derived quantitative parameters and imaging features for predicting the invasiveness of histologically confirmed subcentimeter adenocarcinomatous nodules: a two-center study.Quantitative imaging in medicine and surgery · 2025Article
- Hypermetabolic pulmonary lesions detection and diagnosis based on PET/CT imaging and deep learning models.European journal of nuclear medicine and molecular imaging · 2025Article
- Article
- Deep learning for malignancy risk estimation of incidental sub-centimeter pulmonary nodules on CT images.European radiology · 2024Article
- Impact of preoperative [Annals of nuclear medicine · 2024Article
- Diagnostic value of FDG PET-CT in differentiating lung adenocarcinoma from squamous cell carcinoma.EJNMMI reports · 2024Article
- An Investigation of the Relationship BetweenCurrent radiopharmaceuticals · 2024Article
- Quantitative parameters of static imaging and fast kinetics imaging inQuantitative imaging in medicine and surgery · 2023Article
- Assessment of Tissue Adequacy by EBUS in Conjunction with PET Scan and Operator's Experience.Clinics and practice · 2022Article
- Quantitative assessment of intratumoral 2-[Quantitative imaging in medicine and surgery · 2022Article
- Toward Improved Outcomes for Patients With Lung Cancer Globally: The Essential Role of Radiology and Nuclear Medicine.JCO global oncology · 2022Review
- Staging and operability of primary lung cancer in Western Cape Province, South Africa.African journal of thoracic and critical care medicine · 2022Article
- Value of PET imaging for radiation therapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021Review
- Computed tomography of the chest in unilateral pleural effusions: outcome of the British Thoracic Society guideline.Journal of thoracic disease · 2019Article
- Why harmonization is needed when using FDG PET/CT as a prognosticator: demonstration with EARL-compliant SUV as an independent prognostic factor in lung cancer.European journal of nuclear medicine and molecular imaging · 2019Article
- [Establishment and Verification of A Novel Predictive Model of Malignancy for Non-solid Pulmonary Nodules].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2019Article
- Iodine-125 interstitial brachytherapy reduces tumor growth via Warburg effect inhibition in non-small cell lung cancer A549 ×enografts.Oncology letters · 2018Article
- The feasibility of prostate-specific membrane antigen positron emission tomography(PSMA PET/CT)-guided radiotherapy in oligometastatic prostate cancer patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePositron emission tomography-computed tomography (PET-CT) is a resource-demanding imaging modality with increasing popularity in the workup of patients with suspected or proven lung cancer.
methodsTo review the clinical usefulness of this imaging modality in the diagnosis, staging, and pre-operative evaluation, we conducted a systematic literature search, review, and quality assessment using the rapid evidence assessment toolkit and the Oxford Centre for Evidence-Based Medicine methodology. The literature search resulted in 4,208 records including 918 reviews, of which 139 met the predefined criteria and were read in full to identify relevant original articles on F-18 FDG PET-CT (1) in the evaluation of solitary pulmonary nodules (n = 14), (2) in curative-intent treatment trials (n = 9), and (3) in planning of invasive procedures (n = 18).
resultsWe found the following important results from the literature review: 1) PET-CT can rule out malignancy in most solitary pulmonary nodules due to high sensitivity (recommendation level A). 2) PET-CT reduces the number of futile treatment trials (recommendation level A). 3) The sensitivity of PET-CT in general is insufficient to rule out mediastinal lymph node metastasis (recommendation level A).
conclusionsᅟ 1) With few exceptions, solitary pulmonary nodules can safely be considered benign if the PET-CT scan is negative. Exceptions consist of small (<1 cm) and non-solid, solitary pulmonary nodules. These abnormalities should be followed up by CT in a structured programme. 2) No curative-intent treatment should be commenced until a PET-CT scan has excluded occult distant metastases. 3) In general, lymph node metastasis in the mediastinum cannot be ruled out on the basis of a negative PET-CT, and confirmative invasive staging should be performed in most patients before mediastinal metastasis is confirmed or ruled out.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.