Evidence map›Paper›PMID 27164703›Full record

ArticleNeurology2016

Neonatal seizures triple the risk of a remote seizure after perinatal ischemic stroke.

Christine K Fox, Hannah C Glass, Stephen Sidney, Sabrina E Smith, Heather J Fullerton

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
19.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.

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  13. Short-term outcomes after a neonatal arterial ischemic stroke.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christine K FoxFrom the Departments of Neurology (C.K.F., H.C.G., H.J.F.), Pediatrics (C.K.F., H.C.G., H.J.F.), and Epidemiology and Biostatistics (H.C.G.), University of California, San Francisco; the Division of Research (S.S.), Kaiser Permanente Northern California, Oakland; and the Division of Pediatric Neurology (S.E.S.), Kaiser Permanente Oakland Medical Center, CA. Christine.Fox@ucsf.edu.
Hannah C GlassFrom the Departments of Neurology (C.K.F., H.C.G., H.J.F.), Pediatrics (C.K.F., H.C.G., H.J.F.), and Epidemiology and Biostatistics (H.C.G.), University of California, San Francisco; the Division of Research (S.S.), Kaiser Permanente Northern California, Oakland; and the Division of Pediatric Neurology (S.E.S.), Kaiser Permanente Oakland Medical Center, CA.
Stephen SidneyFrom the Departments of Neurology (C.K.F., H.C.G., H.J.F.), Pediatrics (C.K.F., H.C.G., H.J.F.), and Epidemiology and Biostatistics (H.C.G.), University of California, San Francisco; the Division of Research (S.S.), Kaiser Permanente Northern California, Oakland; and the Division of Pediatric Neurology (S.E.S.), Kaiser Permanente Oakland Medical Center, CA.
Sabrina E SmithFrom the Departments of Neurology (C.K.F., H.C.G., H.J.F.), Pediatrics (C.K.F., H.C.G., H.J.F.), and Epidemiology and Biostatistics (H.C.G.), University of California, San Francisco; the Division of Research (S.S.), Kaiser Permanente Northern California, Oakland; and the Division of Pediatric Neurology (S.E.S.), Kaiser Permanente Oakland Medical Center, CA.
Heather J FullertonFrom the Departments of Neurology (C.K.F., H.C.G., H.J.F.), Pediatrics (C.K.F., H.C.G., H.J.F.), and Epidemiology and Biostatistics (H.C.G.), University of California, San Francisco; the Division of Research (S.S.), Kaiser Permanente Northern California, Oakland; and the Division of Pediatric Neurology (S.E.S.), Kaiser Permanente Oakland Medical Center, CA.
Kaiser Permanente · US

Funding

Clinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9M
VIPS: Vascular Effects of Infection in Pediatric StrokeR01NS062820 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEVEBER, GABRIELLE ALINE, FULLERTON, HEATHER J · 2009 to 2013
$6.6M
Translating discoveries in neurological diseases of infancy and childhoodK12NS001692 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FULLERTON, HEATHER J · 1993 to 2018
$6.4M
MRI Mechanisms of Adverse Outcome in Preterm Infants with SeizuresK23NS066137 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLASS, HANNAH CRANLEY · 2010 to 2014
$858k
The Role of Infection in Childhood StrokeK02NS053883 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FULLERTON, HEATHER J · 2006 to 2010
$831k
NCATS NIH HHS KL2 TR000143NINDS NIH HHS K02 NS053883NINDS NIH HHS K12 NS001692NINDS NIH HHS K23 NS066137NINDS NIH HHS R01 NS062820
6 · The paper itself

Abstract

objectivesTo determine incidence rates and risk factors of remote seizure after perinatal arterial ischemic stroke.

methodsWe retrospectively identified a population-based cohort of children with perinatal arterial ischemic stroke (presenting acutely or in a delayed fashion) from a large Northern Californian integrated health care system. We determined incidence and predictors of a remote seizure (unprovoked seizure after neonatal period, defined as 28 days of life) by survival analyses, and measured epilepsy severity in those with active epilepsy (≥1 remote seizure and maintenance anticonvulsant treatment) at last follow-up.

resultsAmong 87 children with perinatal stroke, 40 (46%) had a seizure in the neonatal period. During a median follow-up of 7.1 years (interquartile range 3.2-10.5), 37 children had ≥1 remote seizure. Remote seizure risk was highest during the first year of life, with a 20% (95% confidence interval [CI] 13%-30%) cumulative incidence by 1 year of age, 46% (CI 35%-58%) by 5 years, and 54% (CI 41%-67%) by 10 years. Neonatal seizures increased the risk of a remote seizure (hazard ratio 2.8, CI 1.3-5.8). Children with neonatal seizures had a 69% (CI 48%-87%) cumulative incidence of remote seizure by age 10 years. Among the 24 children with active epilepsy at last follow-up, 8 (33%) were having monthly seizures despite an anticonvulsant and 7 (29%) were on more than one anticonvulsant.

conclusionsRemote seizures and epilepsy, including medically refractory epilepsy, are common after perinatal stroke. Neonatal seizures are associated with nearly 3-fold increased remote seizure risk.

Indexed as

Brain IschemiaCaliforniaCerebral PalsyChildChild, PreschoolFollow-Up StudiesHumansIncidenceInfant, NewbornKaplan-Meier EstimateProportional Hazards ModelsRetrospective StudiesRisk FactorsSeizuresSeverity of Illness IndexStroke

Identifiers

PMID27164703
PMCPMC4898314
OpenAlexW2346229963

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.