Evidence map›Paper›PMID 27164678›Full record

ArticleNeurology2016

Impaired renal function is associated with brain atrophy and poststroke cognitive decline.

Eitan Auriel, Efrat Kliper, Shani Shenhar-Tsarfaty, Jeremy Molad, Shlomo Berliner, Itzhak Shapira, Dafna Ben-Bashat, Ludmila Shopin, Oren Tene, Gary A Rosenberg and 2 more

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In one paragraph

Article in Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Association of impaired kidney function with dementia and brain pathologies: A community-based cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  7. Cognitive and vascular function in older adults with and without CKD.Aging clinical and experimental research · 2021
    Article
  8. Diabetes, Albuminuria and the Kidney-Brain Axis.Journal of clinical medicine · 2021
    Review
  9. Article
  10. Review
  11. Observational
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Eitan AurielFrom the Department of Neurology (E.A., E.K., S.S.-T., J.M., S.B., I.S., L.S., O.T., N.M.B., E.B.A.) and Functional Brain Center (D.B.-B.), Tel Aviv Sourasky Medical Center; Sackler Faculty of Medicine (E.A., E.K., S.B., I.S., D.B.-B., N.M.B.), Tel Aviv University, Israel; and Department of Neurology (G.A.R.), University of New Mexico Health Sciences Center, Albuquerque. eitanman1@gmail.com.
Efrat KliperFrom the Department of Neurology (E.A., E.K., S.S.-T., J.M., S.B., I.S., L.S., O.T., N.M.B., E.B.A.) and Functional Brain Center (D.B.-B.), Tel Aviv Sourasky Medical Center; Sackler Faculty of Medicine (E.A., E.K., S.B., I.S., D.B.-B., N.M.B.), Tel Aviv University, Israel; and Department of Neurology (G.A.R.), University of New Mexico Health Sciences Center, Albuquerque.
Shani Shenhar-TsarfatyFrom the Department of Neurology (E.A., E.K., S.S.-T., J.M., S.B., I.S., L.S., O.T., N.M.B., E.B.A.) and Functional Brain Center (D.B.-B.), Tel Aviv Sourasky Medical Center; Sackler Faculty of Medicine (E.A., E.K., S.B., I.S., D.B.-B., N.M.B.), Tel Aviv University, Israel; and Department of Neurology (G.A.R.), University of New Mexico Health Sciences Center, Albuquerque.
Jeremy MoladFrom the Department of Neurology (E.A., E.K., S.S.-T., J.M., S.B., I.S., L.S., O.T., N.M.B., E.B.A.) and Functional Brain Center (D.B.-B.), Tel Aviv Sourasky Medical Center; Sackler Faculty of Medicine (E.A., E.K., S.B., I.S., D.B.-B., N.M.B.), Tel Aviv University, Israel; and Department of Neurology (G.A.R.), University of New Mexico Health Sciences Center, Albuquerque.
Shlomo BerlinerFrom the Department of Neurology (E.A., E.K., S.S.-T., J.M., S.B., I.S., L.S., O.T., N.M.B., E.B.A.) and Functional Brain Center (D.B.-B.), Tel Aviv Sourasky Medical Center; Sackler Faculty of Medicine (E.A., E.K., S.B., I.S., D.B.-B., N.M.B.), Tel Aviv University, Israel; and Department of Neurology (G.A.R.), University of New Mexico Health Sciences Center, Albuquerque.
Itzhak ShapiraFrom the Department of Neurology (E.A., E.K., S.S.-T., J.M., S.B., I.S., L.S., O.T., N.M.B., E.B.A.) and Functional Brain Center (D.B.-B.), Tel Aviv Sourasky Medical Center; Sackler Faculty of Medicine (E.A., E.K., S.B., I.S., D.B.-B., N.M.B.), Tel Aviv University, Israel; and Department of Neurology (G.A.R.), University of New Mexico Health Sciences Center, Albuquerque.
Dafna Ben-BashatFrom the Department of Neurology (E.A., E.K., S.S.-T., J.M., S.B., I.S., L.S., O.T., N.M.B., E.B.A.) and Functional Brain Center (D.B.-B.), Tel Aviv Sourasky Medical Center; Sackler Faculty of Medicine (E.A., E.K., S.B., I.S., D.B.-B., N.M.B.), Tel Aviv University, Israel; and Department of Neurology (G.A.R.), University of New Mexico Health Sciences Center, Albuquerque.
Ludmila ShopinFrom the Department of Neurology (E.A., E.K., S.S.-T., J.M., S.B., I.S., L.S., O.T., N.M.B., E.B.A.) and Functional Brain Center (D.B.-B.), Tel Aviv Sourasky Medical Center; Sackler Faculty of Medicine (E.A., E.K., S.B., I.S., D.B.-B., N.M.B.), Tel Aviv University, Israel; and Department of Neurology (G.A.R.), University of New Mexico Health Sciences Center, Albuquerque.
Oren TeneFrom the Department of Neurology (E.A., E.K., S.S.-T., J.M., S.B., I.S., L.S., O.T., N.M.B., E.B.A.) and Functional Brain Center (D.B.-B.), Tel Aviv Sourasky Medical Center; Sackler Faculty of Medicine (E.A., E.K., S.B., I.S., D.B.-B., N.M.B.), Tel Aviv University, Israel; and Department of Neurology (G.A.R.), University of New Mexico Health Sciences Center, Albuquerque.
Gary A RosenbergFrom the Department of Neurology (E.A., E.K., S.S.-T., J.M., S.B., I.S., L.S., O.T., N.M.B., E.B.A.) and Functional Brain Center (D.B.-B.), Tel Aviv Sourasky Medical Center; Sackler Faculty of Medicine (E.A., E.K., S.B., I.S., D.B.-B., N.M.B.), Tel Aviv University, Israel; and Department of Neurology (G.A.R.), University of New Mexico Health Sciences Center, Albuquerque.
Natan M BornsteinFrom the Department of Neurology (E.A., E.K., S.S.-T., J.M., S.B., I.S., L.S., O.T., N.M.B., E.B.A.) and Functional Brain Center (D.B.-B.), Tel Aviv Sourasky Medical Center; Sackler Faculty of Medicine (E.A., E.K., S.B., I.S., D.B.-B., N.M.B.), Tel Aviv University, Israel; and Department of Neurology (G.A.R.), University of New Mexico Health Sciences Center, Albuquerque.
Einor Ben AssayagFrom the Department of Neurology (E.A., E.K., S.S.-T., J.M., S.B., I.S., L.S., O.T., N.M.B., E.B.A.) and Functional Brain Center (D.B.-B.), Tel Aviv Sourasky Medical Center; Sackler Faculty of Medicine (E.A., E.K., S.B., I.S., D.B.-B., N.M.B.), Tel Aviv University, Israel; and Department of Neurology (G.A.R.), University of New Mexico Health Sciences Center, Albuquerque.
Tel Aviv University · IL

Funding

Pathobiology of Vascular Cognitive ImpairmentR01NS052305 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROSENBERG, GARY ALLEN · 2006 to 2016
$4.3M
NINDS NIH HHS R01 NS052305
6 · The paper itself

Abstract

objectiveTo evaluate the interrelationship among impaired renal function, brain pathology on imaging, and cognitive decline in a longitudinal poststroke cohort.

methodsThe Tel Aviv Brain Acute Stroke Cohort study is a prospective cohort of mild-moderate ischemic stroke/TIA survivors without dementia who underwent a 3T MRI and were cognitively assessed at admission and for 24 months following stroke. Renal function was evaluated at admission by creatinine clearance (CCl) estimation. The volumes of ischemic lesions and preexisting white matter hyperintensities (WMH), brain atrophy, and microstructural changes of the normal-appearing white matter tissue were measured using previously validated methods.

resultsBaseline data were available for 431 participants. Participants with a CCl <60 mL/min at baseline performed significantly worse in all cognitive tests over time (p = 0.001) than those with a CCl ≥60 mL/min and had larger WMH volume and cortical atrophy and smaller hippocampal volume (all p < 0.001). After 2 years, 15.5% of the participants were diagnosed with cognitive impairment. Multiple logistic regression analysis, controlling for traditional risk factors, suggested CCl <60 mL/min at baseline as a significant predictor for the development of cognitive impairment 2 years after the index stroke (odds ratio 2.01 [95% confidence interval 1.03-3.92], p = 0.041).

conclusionsImpaired renal function is associated with increased WMH volume and cortical atrophy, known biomarkers of the aging brain, and is a predictor for cognitive decline 2 years after stroke/TIA. Decreased renal function may be associated with cerebral small vessel disease underlying poststroke cognitive decline, suggesting a new target for early intervention.

Indexed as

AgedAtrophyBrainBrain IschemiaCognitive DysfunctionCreatineDiffusion Tensor ImagingFemaleFollow-Up StudiesHumansKidneyLogistic ModelsMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsCreatine

Identifiers

PMID27164678
PMCPMC10687612
OpenAlexW2343050887

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.