ArticleNutrients2016
Influence of Gender and SNPs in GPX1 Gene on Biomarkers of Selenium Status in Healthy Brazilians.
Article in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03111355 (Genetic Variants in Selenoprotein Genes and Gender Influence Biomarkers of Se Status in Response to Brazil Nut Supplementation in Healthy Brazilians), which is not on this map. Cited by 10 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Variants in Selenoprotein Genes and Gender Influence Biomarkers of Se Status in Response to Brazil Nut Supplementation in Healthy Brazilians
Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Selenium intake is associated with gait speed in very old adults.Frontiers in aging · 2025Article
- The association between dietary selenium intake and telomere length in hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Arsenic exposure and increasedRedox biochemistry and chemistry · 2023Article
- Brain region- and sex-specific transcriptional profiles of microglia.Frontiers in psychiatry · 2022Article
- Supplemental Dietary Selenohomolanthionine Improve Antioxidant Activity and Immune Function in Weaned Beagle Puppies.Frontiers in veterinary science · 2021Article
- Association between GPx-1 polymorphisms and personality traits in healthy Chinese-Han subjects.Brain and behavior · 2020Article
- The Relevance of Selenium Status in Rheumatoid Arthritis.Nutrients · 2020Review
- SEXUAL DIMORPHISM IN SELENIUM METABOLISM AND SELENOPROTEINS.Free radical biology & medicine · 2018Review
- Role of glutathione peroxidase 1 in glucose and lipid metabolism-related diseases.Free radical biology & medicine · 2018Review
- Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study.Nutrients · 2018Observational
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selenium (Se) status varies worldwide as a result of natural variation of Se content in soils, dietary pattern, and the presence of SNPs. Further, Se status in Brazilians and its relationship between genetic variation and Se biomarkers is unknown. This work investigated the association between SNPs in glutathione peroxidase genes and biomarkers of Se status in healthy Brazilians. The study was conducted in 116 healthy adults in São Paulo, Brazil. Plasma and erythrocyte Se were measured by HGFAAS. Erythrocyte GPx (eGPx) activity was measured spectrometrically in a biochemical analyzer. Genotypes were determined by real-time PCR using Taqman(®) Assays. eGPx activity was higher in females compared with males. Lower erythrocyte Se concentrations were found in heterozygous GC carriers for GPX1 rs8179169. eGPx activity was higher in females with the common genotypes, except for rs8179169. GC carriers for rs8179169 had lower erythrocyte Se in both genders, and only male carriers of the variant alleles of both rs1050450 and rs1800668 had higher eGPx activity. In conclusion, the genotype for SNPs in GPX1 and gender affected biomarkers of Se status in this pilot study with healthy Brazilians.
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