Evidence map›Paper›PMID 27163191›Full record

ArticleNeuropharmacology2016

Chronic variable stress and intravenous methamphetamine self-administration - Role of individual differences in behavioral and physiological reactivity to novelty.

S B Taylor, L R Watterson, P R Kufahl, N E Nemirovsky, S E Tomek, C D Conrad, M F Olive

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

S B TaylorDepartment of Psychology, Arizona State University, Tempe, AZ, USA. Electronic address: taylor@hendrix.edu.
L R WattersonDepartment of Psychology, Arizona State University, Tempe, AZ, USA.
P R KufahlDepartment of Psychology, Arizona State University, Tempe, AZ, USA.
N E NemirovskyDepartment of Psychology, Arizona State University, Tempe, AZ, USA.
S E TomekDepartment of Psychology, Arizona State University, Tempe, AZ, USA.
C D ConradDepartment of Psychology, Arizona State University, Tempe, AZ, USA; Interdisciplinary Graduate Program in Neuroscience, Arizona State University, Tempe, AZ, USA.
M F OliveDepartment of Psychology, Arizona State University, Tempe, AZ, USA; Interdisciplinary Graduate Program in Neuroscience, Arizona State University, Tempe, AZ, USA. Electronic address: foster.olive@asu.edu.
Arizona State University · US

Funding

mGluR5 antagonists for methamphetamine addictionR01DA025606 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI OLIVE, M. FOSTER · 2009 to 2012
$1.2M
NIDA NIH HHS R01 DA025606
6 · The paper itself

Abstract

Stress is a contributing factor to the development and maintenance of addiction in humans. However, few studies have shown that stress potentiates the rewarding and/or reinforcing effects of methamphetamine in rodent models of addiction. The present study assessed the effects of exposure to 14 days of chronic variable stress (CVS), or no stress as a control (CON), on the rewarding and reinforcing effects of methamphetamine in adult rats using the conditioned place preference (Experiment 1) and intravenous self-administration (Experiment 2) paradigms. In Experiment 2, we also assessed individual differences in open field locomotor activity, anxiety-like behavior in the elevated plus maze (EPM), and physiological responses to a novel environment as possible predictors of methamphetamine intake patterns. Exposure to CVS for 14 days did not affect overall measures of methamphetamine conditioned reward or reinforcement. However, analyses of individual differences and direct vs. indirect effects revealed that rats exhibiting high physiological reactivity and locomotor activity in the EPM and open field tests self-administered more methamphetamine and reached higher breakpoints for drug reinforcement than rats exhibiting low reactivity. In addition, CVS exposure significantly increased the proportion of rats that exhibited high reactivity, and high reactivity was significantly correlated with increased levels of methamphetamine intake. These findings suggest that individual differences in physiological and locomotor reactivity to novel environments, as well as their interactions with stress history, predict patterns of drug intake in rodent models of methamphetamine addiction. Such predictors may eventually inform future strategies for implementing individualized treatment strategies for amphetamine use disorders.

Indexed as

IndividualityAdministration, IntravenousAnimalsBehavior, AddictiveChronic DiseaseExploratory BehaviorLocomotionMaleMethamphetamineRatsRats, Sprague-DawleySelf AdministrationStress, PsychologicalMethamphetamineChronic stressIndividual differencesLocomotorMethamphetaminePlace preferenceReactivitySelf-administration

Identifiers

PMID27163191
PMCPMC4912961
OpenAlexW2346263748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.