Observational studyClinical and experimental immunology2016
Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis.
Observational study in Clinical and experimental immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 30 citations in OpenAlex.
- Extremely Preterm Infants Have Significant Alterations in Their Conventional T Cell Compartment during the First Weeks of Life.Journal of immunology (Baltimore, Md. : 1950) · 2020Trial
- Immune Impairment in Preterm Neonates and Its Impact on Morbidity.Indian journal of pediatrics · 2026Review
- The timing of antenatal glucocorticoids determines the receptor sensitivity in preterm infants.The Journal of clinical endocrinology and metabolism · 2026Article
- Infants < 90 days of age with late-onset sepsis display disturbances of the microbiome-immunity interplay.Infection · 2025Article
- Lymphopenia in sepsis: a narrative review.Critical care (London, England) · 2024Review
- Regulatory T cell homing and activation is a signature of neonatal sepsis.Frontiers in immunology · 2024Article
- Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression.Military Medical Research · 2022Article
- Group B streptococci infection model shows decreased regulatory capacity of cord blood cells.Pediatric research · 2022Article
- Look Who's Talking: Host and Pathogen Drivers ofInternational journal of molecular sciences · 2022Review
- Modulatory activity of adenosine on the immune response in cord and adult blood.Pediatric research · 2021Article
- Five Year Follow Up of Extremely Low Gestational Age Infants after Timely or Delayed Administration of Routine Vaccinations.Vaccines · 2021Article
- Infants Younger Than 90 Days Admitted for Late-Onset Sepsis Display a Reduced Abundance of Regulatory T Cells.Frontiers in immunology · 2021Observational
- Inhibition of lipopolysaccharide-induced inflammation via the protective role of T regulatory cells in the fetal liver in a late-pregnancy preterm mouse model.Clinics (Sao Paulo, Brazil) · 2020Article
- Increased Regulatory T Cells Precede the Development of Bronchopulmonary Dysplasia in Preterm Infants.Frontiers in immunology · 2020Observational
- T Cells in Preterm Infants and the Influence of Milk Diet.Frontiers in immunology · 2020Review
- S100-Alarmins Are Essential Pilots of Postnatal Innate Immune Adaptation.Frontiers in immunology · 2020Review
- Cord blood granulocytic myeloid-derived suppressor cells impair monocyte T cell stimulatory capacity and response to bacterial stimulation.Pediatric research · 2019Article
- Granulocytic myeloid-derived suppressor cells (GR-MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period.Clinical and experimental immunology · 2018Article
- Sepsis-Induced Immunosuppression in Neonates.Frontiers in pediatrics · 2018Review
- The Microbiome and Preterm Birth: A Change in Paradigm with Profound Implications for Pathophysiologic Concepts and Novel Therapeutic Strategies.BioMed research international · 2018Review
Corrections and comments
- Erratum issuedErratum.2016
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The predisposition of preterm neonates to invasive infection is, as yet, incompletely understood. Regulatory T cells (Tregs ) are potential candidates for the ontogenetic control of immune activation and tissue damage in preterm infants. It was the aim of our study to characterize lymphocyte subsets and in particular CD4(+) CD25(+) forkhead box protein 3 (FoxP3)(+) Tregs in peripheral blood of well-phenotyped preterm infants (n = 117; 23 + 0 - 36 + 6 weeks of gestational age) in the first 3 days of life in comparison to term infants and adults. We demonstrated a negative correlation of Treg frequencies and gestational age. Tregs were increased in blood samples of preterm infants compared to term infants and adults. Notably, we found an increased Treg frequency in preterm infants with clinical early-onset sepsis while cause of preterm delivery, e.g. chorioamnionitis, did not affect Treg frequencies. Our data suggest that Tregs apparently play an important role in maintaining maternal-fetal tolerance, which turns into an increased sepsis risk after preterm delivery. Functional analyses are needed in order to elucidate whether Tregs have potential as future target for diagnostics and therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.