ArticleInternational journal of cancer2016
Tobacco-specific N-nitrosamines and polycyclic aromatic hydrocarbons in cigarettes smoked by the participants of the Shanghai Cohort Study.
Article in International journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- A cigarette compound-induced tumor microenvironment promotes sorafenib resistance in hepatocellular carcinoma via the 14-3-3η-modified tumor-associated proteome.Chinese medical journal · 2026Article
- Perioperative cognitive dysfunction in bladder cancer patients, causal factors, and possible interventions.Frontiers in medicine · 2026Review
- Environmental Xenobiotics and Epigenetic Modifications: Implications for Human Health and Disease.Journal of xenobiotics · 2025Review
- Removal of Tobacco Specific Carcinogenic Nitrosamines in Mainstream Cigarette Smoke and Aqueous SolutionA Review.ACS omega · 2025Review
- Analytical Methodologies to Detect N-Nitrosamine Impurities in Active Pharmaceutical Ingredients, Drug Products and Other Matrices.Chemical research in toxicology · 2024Review
- AKR1C2 genetic variants mediate tobacco carcinogens metabolism involving bladder cancer susceptibility.Archives of toxicology · 2024Article
- Consumption of hookahs, e-cigarettes, and classic cigarettes and the impact on medically assisted reproduction treatment.Scientific reports · 2024Article
- Advanced models for respiratory disease and drug studies.Medicinal research reviews · 2023Review
- Effects of tobacco nitrate content on free radical levels in mainstream smoke.Free radical biology & medicine · 2022Article
- Carcinogenic components of tobacco and tobacco smoke: A 2022 update.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2022Review
- Emerging and multifaceted role of neutrophils in lung cancer.Translational lung cancer research · 2021Review
- Quantitation of phenanthrene dihydrodiols in the urine of smokers and non-smokers by gas chromatography-negative ion chemical ionization-tandem mass spectrometry.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2020Article
- Clinical Profile of Male Patients with Non-Small Cell Lung Cancer in Adam Malik General Hospital, Medan, Indonesia.Open access Macedonian journal of medical sciences · 2019Article
- Comprehensive Chemical Characterization of Natural American Spirit Cigarettes.Tobacco regulatory science · 2019Article
- Presence of the Carcinogen N'-Nitrosonornicotine in Saliva of E-cigarette Users.Chemical research in toxicology · 2018Article
- Multi-year Study of PAHs in Mainstream Cigarette Smoke.Tobacco regulatory science · 2018Article
- Unraveling mechanisms of toxicant-induced oxidative stress in cardiovascular disease.Current opinion in toxicology · 2018Article
- Epidemiology of Esophageal Squamous Cell Carcinoma.Gastroenterology · 2018Review
- Constituent Variations in Smokeless Tobacco Purchased in Mumbai, India.Tobacco regulatory science · 2017Article
- Common Risk Factor Approach to Limit Noncommunicable Diseases and Periodontal Disease-The Molecular and Cellular Basis: A Narrative Review.Journal of International Society of Preventive & Community DentistryReview
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Our recent studies on tobacco smoke carcinogen and toxicant biomarkers and cancer risk among male smokers in the Shanghai Cohort Study showed that exposure to tobacco-specific nitrosamines (TSNA) and polycyclic aromatic hydrocarbons (PAH) is prospectively associated with the risk of cancer. These findings support the hypothesis that the smokers' cancer risk is a function of the dose of select tobacco carcinogens and highlight the importance of understanding the factors that affect the intake of these carcinogens by smokers. Given that tobacco constituent exposures are driven, at least in part, by the levels of these constituents in cigarette smoke, we measured mainstream smoke TSNA and PAH levels in 43 Chinese cigarette brands that participants of the Shanghai Cohort Study reported to smoke. In all brands analyzed here, mainstream smoke levels of NNN and NNK, the two carcinogenic TSNA, were generally relatively low, averaging (±SD) 16.8(±25.1) and 14.2(±9.5) ng/cigarette, respectively. The levels of PAH were comparable to those found in U.S. cigarettes, averaging 15(±9) ng/cigarette for benzo[a]pyrene, 119(±66) ng/cigarette for phenanthrene and 37(±19) ng/cigarette for pyrene. Our findings indicate that the generally low levels of NNN and NNK are most likely responsible for the relatively low levels of the corresponding biomarkers in the urine of the Shanghai Cohort Study participants as compared to those found in the U.S. smokers, supporting the role of the levels of these constituents in cigarette smoke in smokers' exposures. Our findings also suggest that, in addition to smoking, other sources contribute to Chinese smokers' exposure to PAH.
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