Evidence map›Paper›PMID 27162783›Full record

ArticleAnnals of translational medicine2016

Metabolic syndrome and components exacerbate osteoarthritis symptoms of pain, depression and reduced knee function.

Hongxing Li, Daniel M George, Ruurd L Jaarsma, Xinzhan Mao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 3 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 108 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Hongxing Li1 Department of Orthopaedic Surgery, Central Hospital of Shaoyang, Shaoyang 422000, China ; 2 Department of Orthopaedics, School of Medicine, Flinders University, Adelaide, Australia ; 3 Department of Orthopaedics and Trauma, Flinders Medical Centre, Adelaide, Australia ; 4 Department of Orthopaedic Surgery, 2nd Xiangya Hospital, Changsha 410011, China.
Daniel M George1 Department of Orthopaedic Surgery, Central Hospital of Shaoyang, Shaoyang 422000, China ; 2 Department of Orthopaedics, School of Medicine, Flinders University, Adelaide, Australia ; 3 Department of Orthopaedics and Trauma, Flinders Medical Centre, Adelaide, Australia ; 4 Department of Orthopaedic Surgery, 2nd Xiangya Hospital, Changsha 410011, China.
Ruurd L Jaarsma1 Department of Orthopaedic Surgery, Central Hospital of Shaoyang, Shaoyang 422000, China ; 2 Department of Orthopaedics, School of Medicine, Flinders University, Adelaide, Australia ; 3 Department of Orthopaedics and Trauma, Flinders Medical Centre, Adelaide, Australia ; 4 Department of Orthopaedic Surgery, 2nd Xiangya Hospital, Changsha 410011, China.
Xinzhan Mao1 Department of Orthopaedic Surgery, Central Hospital of Shaoyang, Shaoyang 422000, China ; 2 Department of Orthopaedics, School of Medicine, Flinders University, Adelaide, Australia ; 3 Department of Orthopaedics and Trauma, Flinders Medical Centre, Adelaide, Australia ; 4 Department of Orthopaedic Surgery, 2nd Xiangya Hospital, Changsha 410011, China.
Flinders Medical Centre · AUXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of this study was to investigate the prevalence of metabolic syndrome and its co-morbidities in patients with primary knee osteoarthritis and to assess if the severity of metabolic syndrome, and components, correlates with the severity of osteoarthritis symptoms.

methodsA case controlled analysis of 70 patients with osteoarthritis compared to a control group of 81 patients. Each patient underwent clinical review including history, examination, and pathology tests. The case-group all had stage IV osteoarthritis as determined by radiographs and intra-operative assessment. In addition a visual analogue scale (VAS), Hospital for Special Surgery knee score (HSS), and Hamilton Depression scores were completed.

resultsThe prevalence of hypertension, obesity, dyslipidemia and metabolic syndrome was significantly higher in the patients with osteoarthritis compared to the control group. There is a significant correlation between the degree of hypertension, the presence of dyslipidemia or hyperglycemia and the severity of osteoarthritis symptoms. Variables hypertension, low HDL-C levels, and the number of co-morbidities were all identified as risk factors for increased osteoarthritis symptoms.

conclusionsThere is a correlation between the number of metabolic disorders, the severity of hypertension and severity of osteoarthritis symptoms. Hypertension and decreased HDL-cholesterol were positive risk factors for increased osteoarthritis symptomatology.

Indexed as

Hyperglycemiahypertensionmetabolic syndrome Xobesityosteoarthritis

Identifiers

PMID27162783
PMCPMC4842398
OpenAlexW2338789173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.