ArticleInternational journal of ophthalmology2016
Research on mouse model of grade II corneal alkali burn.
Article in International journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Promotive effects of 830-nm Photobiomodulation on corneal epithelial wound healing and rho-gtpase expression in a rat alkali burn model.Lasers in medical science · 2026Article
- Overexpression of HE4/WFDC2 gene in mice leads to keratitis and corneal opacity.Open life sciences · 2025Article
- Mitochondria Transplantation Promotes Corneal Epithelial Wound Healing.Investigative ophthalmology & visual science · 2024Article
- LSD1 inhibition by tranylcypromine hydrochloride reduces alkali burn-induced corneal neovascularization and ferroptosis by suppressing HIF-1α pathway.Frontiers in pharmacology · 2024Article
- Snowflake-inspired and blink-driven flexible piezoelectric contact lenses for effective corneal injury repair.Nature communications · 2023Article
- Evaluation of the Algerbrush II rotating burr as a tool for inducing ocular surface failure in a mouse model.Molecular vision · 2023Article
- Concentration-associated pathology of alkali burn in a mouse model using anterior segment optical coherence tomography with angiography.Experimental eye research · 2022Article
- Safety, efficacy and delivery of multiple nucleoside analogs via drug encapsulated carbon (DECON) based sustained drug release platform.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2022Article
- PNP Hydrogel Prevents Formation of Symblephara in Mice After Ocular Alkali Injury.Translational vision science & technology · 2022Article
- An Epithelial Abrasion Model for Studying Corneal Wound Healing.Journal of visualized experiments : JoVE · 2021Article
- Longitudinal Assessment of Alkali Injury on Mouse Cornea Using Anterior Segment Optical Coherence Tomography.Translational vision science & technology · 2021Article
- A Novel Therapeutic Approach to Corneal Alkaline Burn Model by Targeting Fidgetin-Like 2, a Microtubule Regulator.Translational vision science & technology · 2021Article
- Deterioration of wound healing and intense suppression of MMP-9 mRNA expression after short-term administration of different topical glucocorticoids or NSAIDs in an avian model of corneal lesions.Iranian journal of veterinary research · 2021Article
- AMPK Activation by 5-Amino-4-Imidazole Carboxamide Riboside-1-β-D-Ribofuranoside Attenuates Alkali Injury-Induced Corneal Fibrosis.Investigative ophthalmology & visual science · 2020Article
- Identification of novel predictive factors for post surgical corneal haze.Scientific reports · 2019Article
- Experimental modeling of cornea wound healing in diabetes: clinical applications and beyond.BMJ open diabetes research & care · 2019Review
- The mucosal surfaces of both eyes are immunologically linked by a neurogenic inflammatory reflex involving TRPV1 and substance P.Mucosal immunology · 2018Article
- Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing.Journal of visualized experiments : JoVE · 2018Article
- Study on the Role of Short Peptide LCKLSL Targeting ANXA2 in Retinal Neovascularization.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo choose appropriate concentration of sodium hydroxide (NaOH) solution to establish a stable and consistent corneal alkali burn mouse model in grade II.
methodsThe mice (n=60) were randomly divided into four groups and 15 mice each group. Corneal alkali burns were induced by placing circle filter paper soaked with NaOH solutions on the right central cornea for 30s. The concentrations of NaOH solutions of groups A, B, C, and D were 0.1 mol/L, 0.15 mol/L, 0.2 mol/L, and 1.0 mol/L respectively. Then these corneas were irrigated with 20 mL physiological saline (0.9% NaCl). On day 7 postburn, slit lamp microscope was used to observe corneal opacity, corneal epithelial sodium fluorescein staining positive rate, incidence of corneal ulcer and corneal neovascularization, meanwhile pictures of the anterior eyes were taken. Cirrus spectral domain optical coherence tomography was used to scan cornea to observe corneal epithelial defect and corneal ulcer.
resultsCorneal opacity scores (x±s) were not significantly different between the group A and group B (P=0.097). Incidence of corneal ulcer in group B was significantly higher than that in group A (P=0.035). Incidence of corneal ulcer and perforation rate in group B was lower than that in group C. Group C and D had corneal neovascularization, and incidence of corneal neovascularization in group D was significantly higher than that in group C (P=0.000).
conclusionUsing 0.15 mol/L NaOH can establish grade II mouse model of corneal alkali burns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.